Application of a semi-phenomenological model to experimental data of radiation induced pneumopathy in pigs.

Abstract

A semi-phenomenological model has been derived, which describes the inactivation effect on individual cells by survival curves. This model is applied to experimental data of pneumopathy in pigs. The corresponding survival curves as well as the relations between cell survival and complication probability are calculated and discussed. Furthermore, dose-response curves for single dose irradiation and different fractionation schemes are derived. The comparison between the response curve for single dose irradiation and similar curves from the literature shows a good agreement.