{"title":"A case of methotrexate-related lymphoproliferative disorder in the right lung with lung metastasis after left breast cancer surgery","authors":"Shoji Nakata, Hiroki Dohsaka, Takumu Uryuu, Tatsuya Shinguu, Tatsuya Ishii, Yuka Idei","doi":"10.2995/jacsurg.37.515","DOIUrl":null,"url":null,"abstract":"関節リウマチに対してメトトレキサートは重要な治療薬であるが,稀にメトトレキサート関連リンパ増殖性疾患(methotrexate-associated lymphoproliferative disorder,以下MTX-LPD)を起こすことがある.79歳の女性.関節リウマチに対してメトトレキサートを内服中であった.200X年に左乳癌に対し乳房温存手術を行い,200X+11年に左腋窩リンパ節腫大を認めた.リンパ節生検の結果,明らかな悪性所見を認めず.200X+12年にCTで右肺下葉に2個の腫瘍(29 mm,9 mm)と右肺上葉の陰影が指摘された.経気管支肺生検では確定的な病理診断が得られず,右肺下葉切除を施行した.病理でMTX-LPDと乳癌肺転移の合併と診断された.メトトレキサート中止後に右肺上葉の陰影は消失した.メトトレキサート内服の患者ではMTX-LPDを発症する可能性があり注意を要する.","PeriodicalId":498875,"journal":{"name":"The Journal of The Japanese Association for Chest Surgery","volume":"133 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of The Japanese Association for Chest Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2995/jacsurg.37.515","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}