Computational Modeling with Phantom-Tissue Validation of Gold-Nanorod-Enhanced Laser Ablation of Prostate Cancers

IF 2.8 4区工程技术 Q2 ENGINEERING, MECHANICAL

Journal of Heat Transfer-transactions of The Asme Pub Date : 2023-10-06 DOI:10.1115/1.4063651

Huishan Liang, Zhiqin Qian, Hanwei Zhang, Yigang Luo, Michael Moser, Wenjun Zhang, Bing Zhang

{"title":"Computational Modeling with Phantom-Tissue Validation of Gold-Nanorod-Enhanced Laser Ablation of Prostate Cancers","authors":"Huishan Liang, Zhiqin Qian, Hanwei Zhang, Yigang Luo, Michael Moser, Wenjun Zhang, Bing Zhang","doi":"10.1115/1.4063651","DOIUrl":null,"url":null,"abstract":"Abstract The purpose of this study was to develop a computational model for the laser ablation (LA) of prostate cancer, enhanced by gold-nanorods (GNRs) in a phantom-tissue system, and to explore the effect of GNRs on the ablation zone. A prostate biomimetic tissue (PBT) was prepared with different volume fractions of GNRs. Specifically, the computational model was built by considering the change of light properties of PBTs with and without GNRs and introducing the dynamic heat source determined by porcine liver carbonization, reported elsewhere. The computational model was then validated by comparing the simulation and the ex vivo LA experiment in terms of three performance indexes, namely, (i) the spatiotemporal temperature distribution, (ii) ablation zone, and (iii) carbonization zone, with the three volume fractions of GNRs in the PBT model, as mentioned above. Except for minor discrepancies found in the carbonization zone, the proposed model agrees with the experimental data. The effect of GNRs on LA was explored with the help of the model, and nine combinations of the laser powers and the volume fractions of GNRs were tested. The result shows that the ablation zone increases with the increase in the volume fraction of GNRs for all three laser powers used. Two conclusions can be drawn: (1) loading GNRs into the tissues may increase the ablation zone of LA, and (2) the proposed computational model is a reliable tool for predicting the spatiotemporal temperature distribution and the ablation zone of the GNR-enhanced LA.","PeriodicalId":15937,"journal":{"name":"Journal of Heat Transfer-transactions of The Asme","volume":"11 1","pages":"0"},"PeriodicalIF":2.8000,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heat Transfer-transactions of The Asme","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1115/1.4063651","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, MECHANICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract The purpose of this study was to develop a computational model for the laser ablation (LA) of prostate cancer, enhanced by gold-nanorods (GNRs) in a phantom-tissue system, and to explore the effect of GNRs on the ablation zone. A prostate biomimetic tissue (PBT) was prepared with different volume fractions of GNRs. Specifically, the computational model was built by considering the change of light properties of PBTs with and without GNRs and introducing the dynamic heat source determined by porcine liver carbonization, reported elsewhere. The computational model was then validated by comparing the simulation and the ex vivo LA experiment in terms of three performance indexes, namely, (i) the spatiotemporal temperature distribution, (ii) ablation zone, and (iii) carbonization zone, with the three volume fractions of GNRs in the PBT model, as mentioned above. Except for minor discrepancies found in the carbonization zone, the proposed model agrees with the experimental data. The effect of GNRs on LA was explored with the help of the model, and nine combinations of the laser powers and the volume fractions of GNRs were tested. The result shows that the ablation zone increases with the increase in the volume fraction of GNRs for all three laser powers used. Two conclusions can be drawn: (1) loading GNRs into the tissues may increase the ablation zone of LA, and (2) the proposed computational model is a reliable tool for predicting the spatiotemporal temperature distribution and the ablation zone of the GNR-enhanced LA.

查看原文本刊更多论文

金纳米棒增强前列腺癌激光消融的幻影组织验证计算模型

摘要:本研究旨在建立金纳米棒(gnr)在幻影组织系统中增强前列腺癌激光消融(LA)的计算模型，并探讨gnr对消融区域的影响。采用不同体积分数的gnr制备了前列腺仿生组织(PBT)。具体而言，考虑添加和不添加gnr时pbt的光性质变化，并引入由猪肝碳化决定的动态热源，建立了计算模型。通过对比模拟和离体LA实验，对PBT模型中gnr的三个体积分数(1)时空温度分布、(2)烧蚀区和(3)碳化区)三个性能指标进行验证。除了在炭化区发现的微小差异外，所提出的模型与实验数据一致。利用该模型探讨了gnr对LA的影响，并对激光功率和gnr体积分数的9种组合进行了测试。结果表明，在三种激光功率下，随着gnr体积分数的增加，烧蚀区增大。可以得出两个结论:(1)在组织中加载gnr会增加LA的消融区域;(2)所建立的计算模型是预测gnr增强LA的时空温度分布和消融区域的可靠工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Heat Transfer-transactions of The Asme 工程技术-工程：机械

自引率

0.00%

发文量

182

审稿时长

4.7 months

期刊介绍： Topical areas including, but not limited to: Biological heat and mass transfer; Combustion and reactive flows; Conduction; Electronic and photonic cooling; Evaporation, boiling, and condensation; Experimental techniques; Forced convection; Heat exchanger fundamentals; Heat transfer enhancement; Combined heat and mass transfer; Heat transfer in manufacturing; Jets, wakes, and impingement cooling; Melting and solidification; Microscale and nanoscale heat and mass transfer; Natural and mixed convection; Porous media; Radiative heat transfer; Thermal systems; Two-phase flow and heat transfer. Such topical areas may be seen in: Aerospace; The environment; Gas turbines; Biotechnology; Electronic and photonic processes and equipment; Energy systems, Fire and combustion, heat pipes, manufacturing and materials processing, low temperature and arctic region heat transfer; Refrigeration and air conditioning; Homeland security systems; Multi-phase processes; Microscale and nanoscale devices and processes.