Macrocyclic lactone based tri-model therapy to treat humpsore in cattle under humid tropical island ecosystem

IF 0.2 4区农林科学 Q4 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Indian Journal of Animal Sciences Pub Date : 2023-10-06 DOI:10.56093/ijans.v93i10.133137

P PERUMAL, A K DE, D BHATTACHARYA, E B CHAKURKAR

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引用次数: 0

Abstract

Humpsore is a chronic parasitic dermatitis in bovine species; induces severe economic losses to the dairy farmers. Various therapeutic methodologies were tried to treat humpsore in the past; however, they were partially effective against humpsore. Therefore, the present study was designed to assess the effect of tri-model therapy [macrocyclic lactone; Ivermectin, a piperazine derivative; diethylcarbamazine citrate (DECC) and an herbal ointment; Himax™] on treatment of humpsore in Andaman and Nicobar islands. Thirty‐six cattle (n=36 affected) were selected and divided into Gr 1: control (infected without treatment; n=18) and Gr 2: treatment group (infected with treatment; ivermectin, DECC and Himax, n=18) in South Andaman district. In Gr 2, treatment to the ailing animals was given for 45 days. Physiological profiles, hematological profiles, biochemical profiles [total protein, TP; albumin, AL; globulin, GL; creatinine, CR; glucose, GLU; total cholesterol, CHO and urea, URE], liver functional enzymes [aspartate aminotransferase, AST; alanine aminotransferase, ALT and alkaline phosphatase, ALP], mineral profiles, oxidative stress profiles [total antioxidant capacity, TAC; superoxide dismutase, SOD; catalase, CAT and malondialdehyde, MDA] and cortisol were estimated on day 30 of post treatment. Lesion was significantly reduced in day 15 of post‐treatment and completely healed on day 45 of post‐treatment in Gr 2. Physiological profiles, liver functional enzymes, urea, total white blood cell count, differential cell counts, MDA and cortisol were reduced significantly and blood profiles, biochemical profiles, mineral profiles and antioxidant profiles were increased significantly in tri-model therapy treated animals. Therefore, it can be concluded that tri‐model therapy is suitable to treat humpsore in dairy animals.

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基于大环内酯的三模型治疗湿润热带岛屿生态系统下牛驼背病

驼背病是牛的一种慢性寄生虫性皮炎;给奶农造成严重的经济损失。过去曾尝试过各种治疗方法来治疗驼背;然而，它们对驼背有部分效果。因此，本研究旨在评估三模型治疗的效果[大环内酯;伊维菌素，哌嗪衍生物;柠檬酸二乙基卡马嗪(DECC)和草药软膏;Himax™]在安达曼和尼科巴群岛治疗驼背鲸。选择36头牛(n=36头受感染)分为1组:对照组(未治疗的感染;n=18)，第2组:治疗组(感染治疗;伊维菌素，DECC和Himax, n=18)在南安达曼区。在第二组，对患病的动物进行了45天的治疗。生理特征、血液学特征、生化特征[总蛋白、总磷;白蛋白,基地;球蛋白,GL;肌酐、铬;葡萄糖,GLU;总胆固醇，CHO和尿素，URE，肝功能酶[天冬氨酸转氨酶，AST];谷丙转氨酶(ALT)和碱性磷酸酶(ALP)，矿物质谱，氧化应激谱[总抗氧化能力，TAC;超氧化物歧化酶;治疗后第30天测定过氧化氢酶、CAT、丙二醛(MDA)和皮质醇。治疗后第15天病变明显减小，治疗后第45天完全愈合。三模型治疗动物的生理指标、肝功能酶、尿素、总白细胞计数、差异细胞计数、MDA和皮质醇显著降低，血液指标、生化指标、矿物质指标和抗氧化指标显著升高。综上所述，三模型疗法适用于奶牛驼背病的治疗。

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来源期刊

Indian Journal of Animal Sciences 农林科学-奶制品与动物科学

CiteScore

0.60

自引率

25.00%

发文量

220

审稿时长

8 months

期刊介绍： Articles published in The Indian Journal of Animal Sciences encompass a broad range of research topics in animal health and production related to cattle, buffalo, sheep, goat, camel, equines, pig, rabbit, yak, mithun, poultry and fisheries. Studies involving wildlife species and laboratory animal species that address fundamental questions about their biology will also be considered for publication. All manuscripts must present some new development and must be original, timely, significant and scientifically excellent. Papers will be rejected if standards of care of, or procedures performed on animals are not up to those expected of humane veterinary scientists. At a minimum, standards must meet the International Guiding Principles for Biomedical Research involving Animals, as issued by the Council for International Organizations of Medical Sciences. (C.I.O.M.S., c/o WHO, CH 1211 Geneva 27, Switzerland). Articles reporting new animal disease must follow GOI directive as given in detail in Guidelines to Authors.