Bridging the Divide Between Knowledge and Application in the Clinical Practice of Sarcopenia

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-28 DOI:10.33879/amh.143.2023.08087

Liang-Kung Chen

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引用次数: 0

Abstract

S characterized by the age-associated decline in skeletal muscle mass coupled with diminished muscle strength or/and reduced physical performance, has attracted significant research and clinical interest. The Asian Working Group for Sarcopenia (AWGS), in the years 2014 and 2019, issued diagnostic consensus statements which have garnered substantial citation and recognition within the scientific community. Comparing the diagnostic accuracy of the AWGS 2019 consensus with the previous AWGS 2014 guidelines using a prospective cohort of 731 community-dwelling adults aged ≥ 65 years, it was found that AWGS 2019-defined sarcopenia was associated with a significant mortality risk (HR = 1.62, 95% CI 1.04–2.54, p = 0.034) after accounting for confounders, while AWGS 2014-defined sarcopenia was not. The AWGS 2019 criteria exhibited better predictive capability for mortality and were superior in identifying sarcopenia-related mortality risk, suggesting their potential utility in improving health outcomes for older adults. Besides, the AWGS also offers practical guidance on areas including malnutrition, dietary factors, supplementation, lifestyle interventions, and COVID-19's impact, with the goal of enhancing equitable care for this population. Despite the diligent research efforts of the AWGS, the practical application of sarcopenia screening, diagnosis, and treatment within clinical practice remains ambiguous.

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在肌少症的临床实践中弥合知识与应用之间的鸿沟

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.