On Estimation of the Effect Lag of Predictors and Prediction in a Functional Linear Model

IF 0.8 Q4 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Haiyan Liu, Georgios Aivaliotis, Vijay Kumar, Jeanine Houwing-Duistermaat
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引用次数: 0

Abstract

Abstract We propose a functional linear model to predict a functional response using multiple functional and longitudinal predictors and to estimate the effect lags of predictors. The coefficient functions are written as the expansion of a basis system (e.g. functional principal components, splines), and the coefficients of the basis functions are estimated via optimizing a penalization criterion. Then effect lags are determined by simultaneously searching on a prior designed grid mesh based on minimization of a proposed prediction error criterion. Mathematical properties of the estimated regression functions and predicted responses are studied. The performance of the method is evaluated by extensive simulations and a real data analysis application on chronic obstructive pulmonary disease (COPD).
预测器效应滞后的估计与函数线性模型的预测
摘要:我们提出了一个函数线性模型,利用多个函数和纵向预测因子来预测功能响应,并估计预测因子的效应滞后。系数函数被写成基系统的展开(如功能主成分,样条),并且基函数的系数通过优化惩罚准则来估计。然后,基于所提出的预测误差准则的最小化,通过在预先设计的网格上同时搜索来确定效应滞后。研究了估计回归函数和预测响应的数学性质。通过大量的模拟和慢性阻塞性肺疾病(COPD)的实际数据分析应用,对该方法的性能进行了评估。
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来源期刊
Statistics in Biosciences
Statistics in Biosciences MATHEMATICAL & COMPUTATIONAL BIOLOGY-
CiteScore
2.00
自引率
0.00%
发文量
28
期刊介绍: Statistics in Biosciences (SIBS) is published three times a year in print and electronic form. It aims at development and application of statistical methods and their interface with other quantitative methods, such as computational and mathematical methods, in biological and life science, health science, and biopharmaceutical and biotechnological science. SIBS publishes scientific papers and review articles in four sections, with the first two sections as the primary sections. Original Articles publish novel statistical and quantitative methods in biosciences. The Bioscience Case Studies and Practice Articles publish papers that advance statistical practice in biosciences, such as case studies, innovative applications of existing methods that further understanding of subject-matter science, evaluation of existing methods and data sources. Review Articles publish papers that review an area of statistical and quantitative methodology, software, and data sources in biosciences. Commentaries provide perspectives of research topics or policy issues that are of current quantitative interest in biosciences, reactions to an article published in the journal, and scholarly essays. Substantive science is essential in motivating and demonstrating the methodological development and use for an article to be acceptable. Articles published in SIBS share the goal of promoting evidence-based real world practice and policy making through effective and timely interaction and communication of statisticians and quantitative researchers with subject-matter scientists in biosciences.
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