Purification of Copper Radioisotopes for Medical Applications: Chromatographic Methods and Challenges

IF 5.2 2区工程技术 Q1 CHEMISTRY, ANALYTICAL

Separation and Purification Reviews Pub Date : 2023-11-01 DOI:10.1080/15422119.2023.2270469

Alexandra I. Fonseca, Sérgio J. C. Do Carmo, Ivanna Hrynchak, Vítor Alves, Francisco Alves, Antero J. Abrunhosa

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Abstract

ABSTRACTCopper radioisotopes are gaining increasing significance for medical use in recent years for both diagnostic and therapeutic applications. To answer the growing clinical demand, fast, reliable and efficient purification methods to isolate copper isotopes from the irradiated target materials used for their production were developed. Chromatographic techniques have been extensively studied and used to isolate copper isotopes from other metals such as nickel, zinc, or cobalt. This review comprehensively surveys the ion exchange and extraction chromatographic methods developed for copper radioisotope purification to produce radiopharmaceuticals for medical use. Key factors such as target material, isotopic enrichment, number of steps and clinical application are discussed. It concludes with thoughts on automated purification and its importance in the future of the field.KEYWORDS: Purificationcopper radioisotopeschromatographic methodstarget materialseparation methods Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThis work was supported by the Portuguese Foundation for Science and Technology (FCT) under PhD grants [PD/BDE/150681/2020 and PD/BDE/150331/2019].

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医用铜放射性同位素的纯化:色谱方法和挑战

摘要近年来，铜放射性同位素在医学诊断和治疗方面的应用越来越重要。为了满足日益增长的临床需求，开发了快速、可靠、高效的纯化方法，从辐照靶材中分离铜同位素。色谱技术已被广泛研究并用于从镍、锌或钴等其他金属中分离铜同位素。本文综述了离子交换法和萃取色谱法纯化铜放射性同位素制备医用放射性药物的研究进展。讨论了靶材、同位素富集、步骤数和临床应用等关键因素。最后对自动化净化及其在该领域未来的重要性进行了思考。关键词:纯化;铜放射性同位素色谱法;目标物质分离方法;本研究由葡萄牙科学技术基金会(FCT)博士资助项目[PD/BDE/150681/2020和PD/BDE/150331/2019]资助。

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来源期刊

Separation and Purification Reviews 化学-分析化学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

6 months

期刊介绍： Separation & Purification Reviews provides comprehensive summaries and interdisciplinary viewpoints of significant developments in all areas of separation and purification, including innovative methods, apparatus, theories, and applications. The journal presents reviews that cover a large amount of scientific/technical information in a concise and organized manner on topics such as adsorption, centrifugation, chromatography, crystallization, distillation, extraction, filtration, ion exchange, membrane separations of solid, liquid or gaseous materials.