Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-24 DOI:10.2174/0113892029265046231011100327

Ezgi Man, Serap EVRAN

引用次数: 0

Abstract

abstract: Epigenetic changes play an important role in the pathophysiology of autoimmune diseases such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis, rheumatoid arthritis, and COVID-19. There are three main classes of epigenetic alterations: post-translational modifications of histone proteins, control by non-coding RNA and DNA methylation. Since histone modifications can directly affect chromatin structure and accessibility, they can regulate gene expression levels. Abnormal expression and activity of histone deacetylases (HDACs) have been reported in immune mediated diseases. Increased acetylated levels of lysine residues have been suggested to be related to the overexpression of inflammatory genes. This review focuses on the effect of HDAC modifications on histone and non–histone proteins in autoimmune diseases. Furthermore, we discuss the potential therapeutic effect of HDAC inhibitors (HDACi) used in these diseases.

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组蛋白去乙酰化和非组蛋白去乙酰化在炎症疾病和癌症中的治疗潜力

表观遗传变化在变应性哮喘、多发性硬化、肺部疾病、糖尿病、囊性纤维化、动脉粥样硬化、类风湿性关节炎和COVID-19等自身免疫性疾病的病理生理中发挥重要作用。表观遗传改变主要有三类:组蛋白翻译后修饰、非编码RNA控制和DNA甲基化。由于组蛋白修饰可以直接影响染色质结构和可及性，因此它们可以调节基因表达水平。组蛋白去乙酰化酶(hdac)的异常表达和活性在免疫介导的疾病中有报道。赖氨酸残基乙酰化水平的增加被认为与炎症基因的过度表达有关。本文综述了HDAC修饰对自身免疫性疾病中组蛋白和非组蛋白的影响。此外，我们还讨论了HDAC抑制剂(HDACi)在这些疾病中的潜在治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.