Autism Spectrum Disorder and Role of the Inflammatory Theory: A Case Report

Abstract

In this case study, an 8-year-old child from a consanguineous marriage with a complicated pregnancy due to maternal preeclampsia and a normal delivery experienced developmental delays, language problems, social challenges, and other autism spectrum disorder (ASD) symptoms. The child underwent various diagnostic tests, including the M-CHAT, ADI, and ADOS, which all supported an ASD diagnosis. Despite receiving psychomotor, speech, and ABA therapy, the child showed gradual improvement in language skills but continued to exhibit behavioral issues such as irritability, anger outbursts, and sleep disturbances. After experiencing a febrile episode with tonsillitis, followed by knee pain, walking difficulties, chest pain, and shortness of breath, the child was diagnosed with acute rheumatic fever and received corticosteroid therapy, resulting in significant clinical improvement in language, facial expressions, social interactions, and a renewed ASD assessment. The discussion focuses on the potential environmental factors contributing to ASD, emphasizing the role of shared environmental factors in twin studies and genetic factors. The study explores the inflammatory response as a possible common pathway for ASD development, particularly in cases where preeclampsia during pregnancy and its associated inflammation affect the mother and, subsequently, the placenta or fetus. Abnormal angiogenesis and elevated levels of soluble tyrosine kinase 1 (sFlt-1) are discussed as potential factors contributing to fetal neurodevelopmental abnormalities. The text also highlights the role of corticosteroid therapy in improving ASD symptoms, with references to previous studies showing positive responses to corticosteroid treatment in ASD patients. The impact of medications like prednisone and pregnenolone on ASD symptoms and their mechanisms of action, including potential modulation of GABA A receptors, is mentioned. In conclusion, the case study suggests a potential link between ........