Protracted and Tedious-Indolent T Lymphoproliferative Disorder of Gastrointestinal Tract

Abstract

Indolent T lymphoproliferative disorder of gastrointestinal tract is an exceptional disorder associated with infiltration of monoclonal T cells within mucosa of gastrointestinal tract. Generally, a non-destructive infiltrate constituted of miniature, monotonous lymphoid cells demonstrating an immuno-phenotype of CD4+ / CD8- or CD4- / CD8+ appears to infiltrate gastrointestinal mucosa. The exceptionally discerned, indolent T lymphoproliferative disorder of gastrointestinal tract commonly arises within middle aged male subjects, frequently manifests with diarrhoea and exemplifies an indolent clinical course. Although small intestine and colon are commonly incriminated, entire gastrointestinal tract may depict the lesions and no segment of the gut is spared. Indolent T lymphoproliferative disorder represents with a chronic clinical course associated with frequent episodes of disease relapse, inadequate response to cogent chemotherapy and extended survival.