Advances in the Bioregulation of Mesenchymal Stem Cells by Low-Level Laser Therapy During Bone Formation: A Narrative Review

IF 0.7 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Sains Malaysiana Pub Date : 2023-07-31 DOI:10.17576/jsm-2023-5207-14

Yan Pei Wang, Mohamad Arif Awang Nawi, Norma Ab Rahman

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引用次数: 0

Abstract

This article reviews the progress of research on the modulation of the biological effects of low-level laser therapy (LLLT) on Mesenchymal stem cells (MSC) and the influence of the basic LLLT parameters and irradiation scenarios. A thorough search of the literature in the PubMed, Web of Science and Embase databases, including articles published in peer-reviewed journals, was conducted to collect relevant information on LLLT and MSCs. A comprehensive search of PubMed, Web of Science, and Embase databases was performed using the keywords "Low level laser," "mesenchymal stem cells," " cell proliferation," and "osteogenic differentiation." The search was limited to studies published in English between 2009 and 2022, including in vitro and in vivo studies. LLLT has the potential to promote MSC proliferation and osteogenic differentiation, with significant applications in bone tissue engineering. Factors that influence the biological effects of LLLT on MSC include cell type, culture medium, duration of irradiation, the frequency of laser irradiation, irradiation spot size, and type of light flux distribution. The limitations of this review include heterogeneous experimental conditions and the inability to design experiments that consider all influencing factors simultaneously.

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低水平激光治疗骨形成过程中间充质干细胞生物调控的研究进展

本文综述了低水平激光治疗(LLLT)对间充质干细胞(MSC)生物学效应调控的研究进展，以及低水平激光治疗基本参数和照射条件对间充质干细胞生物学效应的影响。在PubMed、Web of Science和Embase数据库中进行了全面的文献检索，包括发表在同行评审期刊上的文章，以收集有关LLLT和msc的相关信息。使用关键词“低水平激光”、“间充质干细胞”、“细胞增殖”和“成骨分化”，对PubMed、Web of Science和Embase数据库进行了全面的搜索。该研究仅限于2009年至2022年间用英文发表的研究，包括体外和体内研究。LLLT具有促进间充质干细胞增殖和成骨分化的潜力，在骨组织工程中具有重要的应用价值。影响LLLT对MSC生物学效应的因素包括细胞类型、培养基、照射时间、激光照射频率、照射光斑大小、光通量分布类型等。本综述的局限性包括实验条件的异质性和无法设计同时考虑所有影响因素的实验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sains Malaysiana MULTIDISCIPLINARY SCIENCES-

CiteScore

1.60

自引率

12.50%

发文量

196

审稿时长

3-6 weeks

期刊介绍： Sains Malaysiana is a refereed journal committed to the advancement of scholarly knowledge and research findings of the several branches of science and technology. It contains articles on Earth Sciences, Health Sciences, Life Sciences, Mathematical Sciences and Physical Sciences. The journal publishes articles, reviews, and research notes whose content and approach are of interest to a wide range of scholars. Sains Malaysiana is published by the UKM Press an its autonomous Editorial Board are drawn from the Faculty of Science and Technology, Universiti Kebangsaan Malaysia. In addition, distinguished scholars from local and foreign universities are appointed to serve as advisory board members and referees.