Significance of corticosteroids binding to blood plasma proteins in the mechanism of the RS-10 radioprotector affecting the function of the adrenal cortex

Abstract

The relevance of research on the preventive properties of chemical radioprotectors is currently due to the need to implement a system of radiation safety measures for the population. The study aimed to investigate the significance of corticosteroid binding to plasma proteins in the mechanism of influence of the radioprotector RS-10 on adrenal cortical function in healthy and irradiated animals. Experiments were carried out on 60 male rabbits of the chinchilla breed. In the first series of experiments, the reaction of the adrenal cortex and the processes of binding them to proteins after administration of RS-10 intact animals were studied; in the second series – the same indicators in animals exposed to RS-10 prophylactic administration.