Exploring of Breast Cancer Characteristic Features and Their Influences on Survival Rates

Abstract

Breast cancer stands as the most predominant form of neoplasm and it remains the main cause of cancer-related deaths among females. Over the last four decades; a significant reduction in breast cancer mortality has been achieved due the substantial progress in the management of the disease.This retrospective study aims to evaluate the clinical and pathological features along with breast cancer molecular sub-types in city of Kirkuk-Iraq. In this study data were collected from 280 breast cancer patient who were under the care of Kirkuk oncology center from April 2020 and for nine months, patient's average age was 50.05 years and the most of the patient diagnosed with luminal A breast cancer (57%) of the cases, with the majority (56.9%) falling within the 41 to 50-year-old age range, results shows a significant correlation between menopausal status and the survival rate (p=0.002). A significant correlation (p=0.002) between tumor stage (AIII) and postmenopausal statutes has been noticed. On the same time a higher survival rate (≥5 years) has been recorded among those who diagnosed with tumor stage AIII, whereas in 85% of the cases who diagnosed with tumor stage IV showed survival rate for less than five years. Results from this study highlights the importance of considering the stage and molecular subtypes along with patient's age in the management of the disease and addressing the outcome associated with luminal A (Her2 negative) breast cancer via developing more reliable diagnoses tools and therapeutic targets among different molecular subtypes and finally enhancing women's awareness of the importance of early detection as a principle objective.