Effect of Oleo-gum-resin of Boswellia serrata Roxb. (Kundur) on Cadmium Chloride Induced Renal Toxicity in Albino rats

Abstract

Kundur (oleo-gum-resin of Boswellia serrata Roxb.) is an ingredient in certain Unani formulations used in kidney disorders. Cadmium is potentially a severe nephrotoxin, because cadmium has a biologic half life of more than 30 years. In the present study the effects of Kundur and its methanol soluble (MS) and methanol insoluble (MINS) fractions were investigated on Cadmium chloride induced nephrotoxicity in Albino rats. The animals of group I and II were administered with 1% CMC (1000mgl/kg, p.o.) and the animals of groups III, IV and V were administered with Kundur (1000mg/kg, p.o.), MS (650mg/kg, p.o.) and MINS (350mg/kg, p.o.) respectively for eight days. Animals in group II, III, IV and V were co-administered Cadmium chloride (3mg/kg/bodyweight) from the fourth day to the end of study (eight day). On the 9th day (after 24h s.c. ingestion) blood samples were withdrawal, blood samples centrifuged and serum was separated to measure the concentration of blood urea nitrogen (BUN) and serum creatinine. Albino rats fed with Kundur and MI fraction showed a significant prevention in the rise of serum markers while MS failed to prevent the rise of these serum makers. These results suggest that Kundur (Boswellia serrata Roxb.) and MINS fraction may have potential to reduce the nephrotoxicity in Albino rats.