SARS-CoV-2-assoziierte Todesfälle innerhalb des ersten Jahres der COVID-19-Pandemie: eine Autopsiestudie

IF 0.4 4区医学 Q4 MEDICINE, LEGAL

Rechtsmedizin Pub Date : 2023-06-28 DOI:10.1007/s00194-023-00636-x

Angelina Autsch, Hannah Ihle, Sandra Kleemann, Juliane Sanft, Maria Hahnemann, Michael Hubig, Mike Philipp, Michael Bauer, Stefanie Deinhardt-Emmer, Nikolaus Gaßler, Gita Mall, Daniel Wittschieber

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引用次数: 1

Abstract

Abstract Background COVID-19 now exists for more than 3 years and has caused almost 7 million deaths worldwide. At the beginning of this study only little was known on the patients’ characteristics and comparative autopsy studies are still rare. Material and methods Between 11 March 2020 and 10 March 2021, 55 consecutive and complete autopsies of individuals who died in association with SARS-CoV‑2 infections were performed shortly after death (median PMI 6.8 h) by the same team. Clinical data were available in 45 of 55 cases. 1st vs. 2nd infection wave cases and male vs. female cases were compared. Results Thirty-five patients were male (63.6%) 20 were female (36.4%), average age 72.4 years. Seventeen cases (30.9%) could be assigned to the 1st and 38 cases (69.1%) to the 2nd infection wave. Forty-two of the decedents (76.4%) died due to COVID-19. Arterial hypertension, obesity, and cardiac hypertrophy were the most frequent detected comorbidities. Discussion The present study corroborates previous research data but also reveals new approaches for further comparative studies. Patient-specific personal and general ICU-related risk factors for the development of thromboembolisms oppose the effects of changes in anticoagulant medication.

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面向蒸联死症候群的第一年

背景2019冠状病毒病(COVID-19)已经存在3年多，在全球造成近700万人死亡。在本研究开始时，对患者的特征知之甚少，比较尸检研究仍然很少。材料和方法在2020年3月11日至2021年3月10日期间，同一团队在死后不久(中位PMI 6.8 h)对55例与SARS-CoV - 2感染相关的死亡个体进行了连续和完整的尸检。55例中有45例有临床资料。第一波与第二波感染病例、男性与女性病例比较。结果男性35例(63.6%)，女性20例(36.4%)，平均年龄72.4岁。第1波感染17例(30.9%)，第2波感染38例(69.1%)。死者中有42人(76.4%)死于新冠肺炎。动脉高血压、肥胖和心脏肥厚是最常见的合并症。本研究证实了以往的研究数据，但也为进一步的比较研究提供了新的途径。患者特异性的个人和一般icu相关的血栓栓塞发展的危险因素反对抗凝药物的变化的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rechtsmedizin MEDICINE, LEGAL-

CiteScore

1.30

自引率

40.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Rechtsmedizin is an internationally recognized journal dealing with all aspects of forensic medicine. It provides information on current developments in forensic pathology, traumatology, traffic medicine, toxicology, serology, insurance medicine, psychopathology and legal medical issues. Freely submitted original papers allow the presentation of important clinical studies and serve scientific exchange. Case reports feature interesting and unique cases thus providing a platform for scientific information and critical discussion. Comprehensive reviews on a specific topical issue focus on providing evidenced based information on all aspects of the field. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.