Fungal infections in patients with progressing COVID-19: pathomorphology and description of clinical cases

Q4 Medicine

Pulmonologiya Pub Date : 2023-09-06 DOI:10.18093/0869-0189-2023-33-5-703-712

M. V. Mnichovich, A. A. Soldatova, S. I. Usmanov, I. A. Shiripenko, O. A. Sidorova, M. V. Lozina, S. V. Snegur, Ju. G. Pavlova, P. P. Baklanov, V. M. Kozeev

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引用次数: 0

Abstract

Invasive pulmonary mycoses are a common complication of severe COVID-19 ( COronaVIrus Disease 2019) and are characterized by rapid spread and high mortality. It is especially important to study the epidemiology and pathomorphology of fungal superinfection in order to understand the main vector of the diagnosis and treatment of this complication. The aim of this paper is to consider aspects of the epidemiology, pathomorphologic picture, and clinical manifestations of invasive pulmonary mycoses associated with COVID-19. Clinical cases of fungal superinfections (candidiasis, aspergillosis) associated with COVID-19 in patients receiving appropriate therapy were presented. Results of autopsy examination and light microscopy with routine staining were analyzed. Macroscopic assessment of lesions and histological examination revealed morphological multiorgan changes typical of the combination of fungal (candidiasis, aspergillosis) and viral infection (COVID-19). Conclusion. The presented data of post-mortem examination are important for both science and clinical practice as they form the basis for finding new ways of treating patients with comorbid pathology and developing a prognostic algorithm.

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进展性COVID-19患者的真菌感染:病理形态学和临床病例描述

侵袭性肺真菌病是重症COVID-19(冠状病毒病2019)的常见并发症，其特点是传播迅速，死亡率高。研究真菌重复感染的流行病学和病理形态学对了解这种并发症的诊断和治疗的主要媒介尤为重要。本文的目的是考虑与COVID-19相关的侵袭性肺真菌病的流行病学，病理形态学和临床表现方面。在接受适当治疗的患者中出现与COVID-19相关的真菌重复感染(念珠菌病、曲霉病)的临床病例。对尸检及常规染色光镜检查结果进行分析。病变的宏观评估和组织学检查显示典型的真菌(念珠菌病、曲霉病)和病毒感染(COVID-19)合并的形态学多器官改变。结论。提出的死后检查数据对科学和临床实践都很重要，因为它们构成了寻找治疗共病病理患者的新方法和发展预后算法的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pulmonologiya Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The aim of this journal is to state a scientific position of the Russian Respiratory Society (RRS) on diagnosis and treatment of respiratory diseases based on recent evidence-based clinical trial publications and international consensuses. The most important tasks of the journal are: -improvement proficiency qualifications of respiratory specialists; -education in pulmonology; -prompt publication of original studies on diagnosis and treatment of respiratory diseases; -sharing clinical experience and information about pulmonology service organization in different regions of Russia; -information on current protocols, standards and recommendations of international respiratory societies; -discussion and consequent publication Russian consensus documents and announcement of RRS activities; -publication and comments of regulatory documents of Russian Ministry of Health; -historical review of Russian pulmonology development. The scientific concept of the journal includes publication of current evidence-based studies on respiratory medicine and their discussion with the participation of Russian and foreign experts and development of national consensus documents on respiratory medicine. Russian and foreign respiratory specialists including pneumologists, TB specialists, thoracic surgeons, allergists, clinical immunologists, pediatricians, oncologists, physiologists, and therapeutists are invited to publish article in the journal.