Blood periostin/procalcitonin index in patients with asthma and asthma-COPD overlap

Q4 Medicine

Pulmonologiya Pub Date : 2023-09-06 DOI:10.18093/0869-0189-2023-33-5-657-662

V. I. Trofimov, D. Z. Baranov, V. N. Mineev

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引用次数: 0

Abstract

The significant prevalence of asthma and asthma-COPD overlap (ACO) necessitates further rationalization of diagnostic and treatment approaches and emphasizes importance of studying the pathogenesis of bronchial obstructive diseases. Well-known markers of allergic and infectious inflammation such as periostin and procalcitonin, respectively, have shown their utility in pulmonology. The aim of this study is to analyze the diagnostic value of blood periostin/procalcitonin index as a complex parameter reflecting both allergic and non-allergic inflammation. Methods. First, we calculated blood periostin/procalcitonin index. Then we compared this index between two groups using the Mann – Whitney test. Results. Patients with non-allergic asthma had lower blood periostin/procalcitonin index compared to the patients with allergic asthma ( p = 0.003). Blood periostin/procalcitonin index correlated well with diagnosis in patients with asthma and ACO in our clinical cases. Conclusion. Blood periostin/ rocalcitonin index has demonstrated its clinical utility as a complex inflammatory parameter. Its high values indicate active allergic inflammation. This index can be used to correct glucocorticoid and antibacterial treatment.

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哮喘和哮喘-慢性阻塞性肺病重叠患者血骨膜素/降钙素原指数

哮喘和哮喘-慢阻肺重叠(asthma- copd overlap, ACO)的显著患病率要求进一步理顺诊断和治疗方法，并强调研究支气管阻塞性疾病发病机制的重要性。众所周知的过敏性炎症和感染性炎症标志物，如骨膜素和降钙素原，分别在肺脏学中显示出它们的用途。本研究的目的是分析血骨膜素/降钙素原指数作为反映过敏性和非过敏性炎症的复杂参数的诊断价值。方法。首先，我们计算血液骨膜素/降钙素原指数。然后我们用Mann - Whitney检验比较两组间的这一指标。结果。非过敏性哮喘患者血骨膜素/降钙素原指数低于过敏性哮喘患者(p = 0.003)。在我们的临床病例中，血骨膜素/降钙素原指数与哮喘和ACO患者的诊断有良好的相关性。结论。血骨膜素/降钙素指数作为一种复杂的炎症参数已被证明具有临床应用价值。它的高值表明活跃的过敏性炎症。该指标可用于糖皮质激素及抗菌治疗的纠正。

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来源期刊

Pulmonologiya Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The aim of this journal is to state a scientific position of the Russian Respiratory Society (RRS) on diagnosis and treatment of respiratory diseases based on recent evidence-based clinical trial publications and international consensuses. The most important tasks of the journal are: -improvement proficiency qualifications of respiratory specialists; -education in pulmonology; -prompt publication of original studies on diagnosis and treatment of respiratory diseases; -sharing clinical experience and information about pulmonology service organization in different regions of Russia; -information on current protocols, standards and recommendations of international respiratory societies; -discussion and consequent publication Russian consensus documents and announcement of RRS activities; -publication and comments of regulatory documents of Russian Ministry of Health; -historical review of Russian pulmonology development. The scientific concept of the journal includes publication of current evidence-based studies on respiratory medicine and their discussion with the participation of Russian and foreign experts and development of national consensus documents on respiratory medicine. Russian and foreign respiratory specialists including pneumologists, TB specialists, thoracic surgeons, allergists, clinical immunologists, pediatricians, oncologists, physiologists, and therapeutists are invited to publish article in the journal.