In vitro transdermal delivery and skin metabolism of salidroside from Rhodiola rosea extract

Abstract

Salidroside (SAL), a phenylpropanoid glycoside extracted from the root of Rhodiola rosea, is known for its pharmacological properties such as antioxidation, antiinflammation, neuroprotective, anti-cancer, and cardioprotective properties (Ching et al., 2015; Zhao et al., 2021). Salidroside is effective in suppressing solar ultraviolet-induced skin inflammation (Wu et al., 2016) and prevents skin carcinogenesis (Kong and Xu, 2016). The hydrophilicity of SAL leads to poor skin permeability, therefore different liposomal nanocarriers for SAL were tested (Zhang, 2015). To improve the SAL transdermal delivery, the transdermal patches containing the dry extract from Rhodiola rosea were formulated. The patch adhesion and dissolution of SAL were tested. The most promising formulations were matrix systems containing two different combinations: gelatine with chitosan or pectin with polyethylene oxide (Haršányová et al., 2018). Based on previous results, the aim of our work was the evaluation of transdermal permeation of SAL from Rhodiola rosea extract