Serum Omentin-1 Levels in Obese Adolescents with Vitamin D Deficiency: A Prospective Cross-Sectional Study

IF 0.4 4区医学 Q4 PEDIATRICS

Iranian Journal of Pediatrics Pub Date : 2023-10-08 DOI:10.5812/ijp-137958

Meltem Erol, Fatih Karan, Abdulrahman Ozel, Ozlem Bostan Gayret, Oguzhan Zengi

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引用次数: 0

Abstract

Background: Vitamin D deficiency is common in obese adolescents. It modulates the release of omentin 1 from adipose tissue. We believe that both vitamin D and omentin 1 affect each other in adipose tissue via inflammation. Objectives: This study aimed to examine serum omentin-1 levels in obese adolescents with vitamin D (Vit D) deficiency. Methods: In this cross-sectional prospective study, 83 obese adolescents were included. Serum 25-hydroxy vitamin D (25(OH)D) concentrations, fasting glucose, and lipid profiles of obese adolescents were studied. At the same time, blood was drawn into a separate tube to study the omentin 1 level. Of the 83 obese cases, 45 with 25(OH)D concentrations below 20 ng/mL were considered as the study group, and 38 with 25(OH)D concentrations ≥ 20 ng/mL as the control group. Serum omentin-1 levels were evaluated and compared. Results: The average 25(OH)D value in the study and control groups was 17.14 ± 2.22 ng/mL and 45.29 ± 24.98 ng/mL, respectively. The average omentin-1 concentration of the control group was 262.5 ± 136.31 ng/mL, and the mean omentin-1 level of the study group was 113.23 ± 15.98 ng/mL. The mean omentin-1 concentrations of the study group were significantly lower compared to the control group (P = 0.0001). There was a significant and positive correlation between omentin-1 and 25(OH)D (r = 0.988 P = 0.0001). In univariate tests, linear regression analysis was carried out with 25(OH)D and omentin-1, and 25(OH)D displayed a significant positive correlation (P = 0.0001). The optimal cut-off point for the serum omentin-1 concentration was 135.01 ng/mL. No significant correlation was determined between omentin-1 and body mass index, lipid profile, glucose, and insulin variables (P > 0.05). Conclusions: We showed significantly low concentrations of serum omentin-1 in obese adolescents with vitamin D deficiency. Serum omentin-1 can be employed as a biomarker in obese adolescents with vitamin D deficiency.

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维生素D缺乏的肥胖青少年血清Omentin-1水平:一项前瞻性横断面研究

背景:维生素D缺乏在肥胖青少年中很常见。它调节脂肪组织中网膜1的释放。我们认为维生素D和网膜1在脂肪组织中通过炎症相互影响。目的:本研究旨在检测维生素D (Vit D)缺乏的肥胖青少年血清网膜-1水平。方法:横断面前瞻性研究纳入83名肥胖青少年。研究了肥胖青少年的血清25-羟基维生素D (25(OH)D)浓度、空腹血糖和脂质谱。同时，将血液抽到另一根管子中，研究网膜1水平。83例肥胖患者中，25(OH)D浓度低于20 ng/mL的45例为研究组，25(OH)D浓度≥20 ng/mL的38例为对照组。评估并比较血清网膜蛋白-1水平。结果:研究组和对照组25(OH)D平均值分别为17.14±2.22 ng/mL和45.29±24.98 ng/mL。对照组的平均omentin-1浓度为262.5±136.31 ng/mL，研究组的平均omentin-1浓度为113.23±15.98 ng/mL。研究组的平均网膜蛋白-1浓度显著低于对照组(P = 0.0001)。omentin-1与25(OH)D呈显著正相关(r = 0.988, P = 0.0001)。单因素检验中，25(OH)D与omentin-1进行线性回归分析，25(OH)D与omentin-1呈显著正相关(P = 0.0001)。血清大网膜蛋白-1浓度最佳临界值为135.01 ng/mL。未发现网膜蛋白-1与体重指数、血脂、葡萄糖和胰岛素变量之间存在显著相关性(P >0.05)。结论:我们发现维生素D缺乏的肥胖青少年血清网膜蛋白-1浓度明显较低。血清网膜蛋白-1可作为肥胖青少年维生素D缺乏症的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Pediatrics 医学-小儿科

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.