Valproic acid ameliorates liver and kidney dysfunctions in type 2 diabetic rats

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Abstract

Type 2 diabetes has been reported to impair both liver and kidney functions but the effect of valproic acid (VPA), an anti-diabetic agent, on liver and kidney dysfunctions in type 2 diabetic models is still elusive. Therefore, this study investigated the effect of VPA on selected functional parameters of liver and kidney in type 2 diabetic rats. Type 2 diabetes was induced in female Wistar rats fed on high-fat diet for 2 weeks and then by intraperitoneal injection of 35 mg/kg body weight (bw) of streptozotocin. The nondiabetic Wistar rats were given water (normal control) while the diabetic groups were administered water (diabetic control), two doses of VPA (50 and 100 mg/kg bw) and 100 mg/kg bw metformin for 14 days. Then, the rats were sacrificed; liver, kidney and serum tissues were collected and analyzed. High-fat diet and streptozotocin significantly (p < 0.05) altered the liver to body weight ratio, kidney to body weight ratio, liver function indices, kidney function indices and enzymes’ activities in the rat liver, kidney and serum but treatment with VPA and metformin ameliorated all the effects. In conclusion, results of this study indicate that VPA ameliorates liver and kidney dysfunctions in type 2 diabetic rats.
丙戊酸改善2型糖尿病大鼠肝肾功能障碍
据报道,2型糖尿病会损害肝肾功能,但抗糖尿病药物丙戊酸(VPA)对2型糖尿病模型肝肾功能的影响尚不明确。因此,本研究考察了VPA对2型糖尿病大鼠肝肾部分功能参数的影响。采用高脂饲料喂养雌性Wistar大鼠2周后,腹腔注射链脲佐菌素35 mg/kg体重(bw)诱导2型糖尿病。非糖尿病Wistar大鼠给予水(正常对照组),糖尿病组给予水(糖尿病对照组),VPA(50和100 mg/kg bw)和二甲双胍(100 mg/kg bw) 2剂量,连续14 d。然后,老鼠被处死;采集肝脏、肾脏及血清组织进行分析。高脂肪饮食对链脲佐菌素的影响显著(p <0.05)可改变肝重比、肾重比、肝功能指数、肾功能指数及肝脏、肾脏和血清酶活性,但VPA和二甲双胍均可改善上述影响。综上所述,本研究结果表明VPA可改善2型糖尿病大鼠肝肾功能障碍。
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