rs1800890 Polymorphism of IL-10 and Susceptibility to Idiopathic Thrombocytopenic Purpura

IF 0.4 Q4 PEDIATRICS
Fatemeh Zeylabi, Mohammad Taha Jalali, Gholam-Abbas Kaydani, Kaveh Jaseb, Najmaldin Saki
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引用次数: 0

Abstract

Abstract Immune thrombocytopenic purpura (ITP) is an immune bleeding disorder that is reported in approximately 2 out of every 100,000 adults with a mean age of 50 years. Several factors such as various genetic backgrounds are associated with the pathogenesis of ITP. Interleukin (IL)-10 is a complicated cytokine that has a role in tumor progression, antitumor immunity, and immune system regulation. rs1800890 is an IL-10 single nucleotide polymorphism linked to lower levels of IL-10. A total of 67 patients with ITP and 70 healthy individuals (controls) were considered in this study. The IL-10 polymorphism was detected by the amplification refractory mutation system–polymerase chain reaction technique. According to our analysis, individual carriers of the AA genotype were less likely to develop ITP. The AT genotype was more common in patients with ITP in comparison to the control group. However, there was no significant association between rs1800890 genotypes (p = 0.775, odds ratio =1.517, 95%) in the acute and chronic groups. We observed that women had a higher mean frequency of this polymorphism (p = 0.0012). The rs1800890 AA genotype was associated with the highest platelet counts. However, the mean platelet volume and platelet distribution width values among alleles of the polymorphisms did not vary significantly. The IL-10 rs1800890 polymorphism may have a role in idiopathic thrombocytopenic purpura etiology. As a result, more research with a larger number of sample sizes is suggested.
IL-10多态性与特发性血小板减少性紫癜易感性的关系
免疫性血小板减少性紫癜(ITP)是一种免疫性出血性疾病,据报道,每10万成人中约有2例,平均年龄为50岁。多种遗传背景等因素与ITP的发病机制有关。白细胞介素(IL)-10是一种复杂的细胞因子,在肿瘤进展、抗肿瘤免疫和免疫系统调节中发挥作用。rs1800890是IL-10单核苷酸多态性,与较低水平的IL-10相关。本研究共纳入67例ITP患者和70例健康个体(对照)。采用扩增难解突变系统-聚合酶链反应技术检测IL-10多态性。根据我们的分析,单个AA基因型携带者发生ITP的可能性较小。与对照组相比,AT基因型在ITP患者中更为常见。然而,急性组和慢性组rs1800890基因型之间无显著相关性(p = 0.775,优势比=1.517,95%)。我们观察到女性具有更高的这种多态性的平均频率(p = 0.0012)。rs1800890 AA基因型与血小板计数最高相关。然而,多态性等位基因间血小板平均体积和血小板分布宽度值无显著差异。IL-10 rs1800890多态性可能在特发性血小板减少性紫癜病因学中起作用。因此,建议进行更多的研究,样本量更大。
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来源期刊
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期刊介绍: The Journal of Pediatric Genetics is an English multidisciplinary peer-reviewed international journal publishing articles on all aspects of genetics in childhood and of the genetics of experimental models. These topics include clinical genetics, molecular genetics, biochemical genetics, medical genetics, dysmorphology, teratology, genetic counselling, genetic engineering, formal genetics, neuropsychiatric genetics, behavioral genetics, community genetics, cytogenetics, hereditary or syndromic cancer genetics, genetic mapping, reproductive genetics, fetal pathology and prenatal diagnosis, multiple congenital anomaly syndromes, and molecular embryology of birth defects. Journal of Pediatric Genetics provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis of childhood genetics. Journal of Pediatric Genetics encourages submissions from all authors throughout the world. The following articles will be considered for publication: editorials, original and review articles, short report, rapid communications, case reports, letters to the editor, and book reviews. The aim of the journal is to share and disseminate knowledge between all disciplines in the field of pediatric genetics. This journal is a publication of the World Pediatric Society: http://www.worldpediatricsociety.org/ The Journal of Pediatric Genetics is available in print and online. Articles published ahead of print are available via the eFirst service on the Thieme E-Journals platform.
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