Luminescent Media Based on Heteroligand Lanthanide Complexes and Lyotropic Mesophases for Bioimaging Application

Abstract

New terbium and europium heteroligand complexes with substituted 1,2,3-triazole – bis-1,3-(4-methylcarboxyl-1,2,3-triazol-1-yl)xylylene have been synthesized. A study of luminescent properties showed that the complexes exhibit high optical characteristics. The luminescence efficiency of [Tb(AcAc)2(TR)(H2O)2], increases by 13 % compared to the monoligand complex [Tb(AcAc)3(H2O)2]. In order to create biocompatible systems, an approach for the solubilization of hydrophobic complexes by incorporating them into the lyomesophase structure of P123/DMSO has been developed. According to polarization optical microscopy, the hybrid system containing 0.2 % of the [Tb(AcAc)3(H2O)2] complex shows a lamellar mesophase. Fluorescence microscopy study showed that the [Eu(TTA)2(TR)(H2O)2] complex is efficiently adsorbed on the surface of the Paramecium caudatum microorganism and exhibits red luminescence allowing visualization of biological objects.