Design of Dendritic Foldamers as Catalysts for Organic Synthesis

IF 0.9 Q4 CHEMISTRY, PHYSICAL
Smitha George, Sherlymole P. Baby, Sreekumar Krishnapillai
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引用次数: 0

Abstract

Background:: Multistranded foldamers mimic biopolymer architecture, through the assembly and folding of intrinsically flexible polymeric chains attached to polyol core have been synthesised here. The synthesised dendritic motifs possess helical cavities with properly arranged active sites. As these cavities are large enough to accommodate guest molecules, their application as synthetic foldamer catalyst were investigated in Knoevenagel and Mannich reactions. Methods:: It is presumed to be the potentiality of dendritic foldamers to form reverse micelle in the interior of helical motif containing many reactive sites. Results:: Inside the dendritic foldamer, the substrates are adequately concentrated, work together in cooperation for ligand-binding, and stabilize the transition state as in enzymes that helps to accelerate the reaction rate many times greater than in bulk solution. Conclusion:: An unrivalled reaction rate and high yield of products were obtained within a short time in both Knoevenagel and Mannich reactions by using dendritic foldamers as catalysts.
枝状折叠体有机合成催化剂的设计
背景:多链折叠体模拟生物聚合物结构,通过装配和折叠内在柔性聚合物链连接到多元醇核心已经合成。合成的树突基序具有螺旋腔,活性位点排列合理。由于这些空腔足够大,可以容纳客体分子,因此研究了它们在Knoevenagel和Mannich反应中作为合成折叠体催化剂的应用。方法:推测树突状折叠体具有在含有许多活性位点的螺旋基序内部形成反胶团的潜力。结果:在树突状折叠体内部,底物被充分浓缩,在配体结合中协同工作,并稳定过渡状态,就像在酶中一样,有助于加速反应速率,比在体溶液中快许多倍。结论:在Knoevenagel反应和Mannich反应中,枝状折叠物均能在短时间内获得较高的反应速率和产率。
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来源期刊
Current Organocatalysis
Current Organocatalysis CHEMISTRY, PHYSICAL-
CiteScore
2.00
自引率
0.00%
发文量
28
期刊介绍: Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.
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