Acute kidney injury and COVID-19 in young adults in intensive care

IF 1.1 4区 医学 Q3 NURSING
José Edilson de Oliveira, Talita Andrade dos Santos, Angélica Gonçalves Silva Belasco, Dulce Aparecida Barbosa, Eduesley Santana Santos, Miguel Angelo de Góes Junior, Carla Roberta Monteiro Miura, Cassiane Dezoti da Fonseca
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Abstract

Objective To describe acute kidney injury prevalence in young adults diagnosed with COVID-19 admitted to the Intensive Care Unit. Methods This is a retrospective, quantitative and analytical study. The sample consisted of young adults (20 to 40 years old) admitted to Intensive Care Units, diagnosed with SARS-CoV-2 infection between March and December 2020. Data were obtained through electronic medical records, and kidney injury acute was defined by the creatinine value, according to the Kidney Disease Improving Global Outcomes guidelines criteria. Statistical significance was p≤0.05. Results A total of 58 young adults were hospitalized, 63.8% of whom were male. Hypertension was present in 39.6%, obesity in 18.9%, and diabetes mellitus in 8.6%. Acute kidney injury was identified in 55.1%, with stage 3 predominating in 43.1% of them. In these patients, the use of mechanical ventilation and vasoactive drugs was significant in 92% as well as respiratory organ dysfunction (80%), followed by renal organ dysfunction (76%). Risk factors such as kidney transplantation or chronic kidney disease and obesity increased by 12.3 and 9.0 times, respectively, the chances of developing acute kidney injury. Conclusion This study demonstrated a high kidney injury prevalence in young adults and its association with previous comorbidities. Obesity, kidney transplantation and chronic kidney disease increased the chance of young adults to develop acute kidney injury, resulting in outcomes in favor of morbidity and mortality.
重症监护青年急性肾损伤与COVID-19
目的了解重症监护病房诊断为COVID-19的年轻成人急性肾损伤患病率。方法回顾性、定量、分析研究。样本包括在2020年3月至12月期间被诊断患有SARS-CoV-2感染的重症监护病房的年轻人(20至40岁)。数据通过电子病历获得,根据肾病改善全球结局指南标准,通过肌酐值定义急性肾损伤。差异有统计学意义p≤0.05。结果共有58名青壮年住院,其中男性占63.8%。高血压39.6%,肥胖18.9%,糖尿病8.6%。急性肾损伤占55.1%,其中以3期为主,占43.1%。在这些患者中,机械通气和血管活性药物的使用占92%,呼吸器官功能障碍占80%,其次是肾器官功能障碍占76%。肾脏移植或慢性肾脏疾病、肥胖等危险因素发生急性肾损伤的可能性分别增加了12.3倍和9.0倍。结论:本研究表明,青壮年肾损伤发生率高,且与既往合并症有关。肥胖、肾移植和慢性肾脏疾病增加了年轻人发生急性肾损伤的机会,导致有利于发病率和死亡率的结果。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
92
审稿时长
4 weeks
期刊介绍: Acta Paulista de Enfermagem – (Acta Paul Enferm.), ISSN 1982-0194, is a [bilingual] technical-scientific electronic publication of the Escola Paulista de Enfermagem – EPE, Universidade Federal de São Paulo – UNIFESP. Our mission: To disseminate the scientific knowledge generated within the rigor of research and ethics methodology. Our objective: To publish results of original research for advancement of practices of clinical, surgical, and management nursing, as well as education, research, and information and communication technology.
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