Probiotics: Therapeutic Strategy on the Prevention and Treatment of Inflammatory Diseases: Obesity, Type 2 Diabetes Mellitus and Celiac Disease

IF 0.8 Q4 NUTRITION & DIETETICS

Current Nutrition & Food Science Pub Date : 2023-10-25 DOI:10.2174/0115734013252358231016181809

Elisa dos Santos Pereira, Chirle de Oliveira Raphaelli, Khadija Bezerra Massaut, Jardel Araújo Ribeiro, Helena Reissig Soares Vitola, Simone Pieniz, Ângela Maria Fiorentini

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Abstract

Background: Recent evidence demonstrates the fundamental role of the gut microbiota in inflammatory diseases, and several mechanisms of action of probiotics in improvement of inflammatory parameters. Objective: The objective of this review was to relate the consumption of probiotic bacteria and its effects on inflammatory diseases, including obesity, type II diabetes and celiac disease. Method: A search was carried out in English, between the years 2011 and 2022, for research articles and clinical trials with humans and in vivo studies. Research showed improvement in cardiovascular risk markers, and improvement in insulin sensitivity, lipid profile and plasma atherogenic index, in obesity with the use of probiotics. In type II diabetes, decreased levels of fasting glucose, glycated hemoglobin, insulin and glycemic index, and increased levels of peptide 1, superoxide dismutase and glutathione peroxidase were observed. Result: In addition to cellular protection of the islets of Langerhans and positive alteration of TNF-α and IL-1β markers. Improvement in the condition of patients with celiac disease was observed, since the neutralization of the imbalance in serotonin levels was observed, reducing the expression of genes of interest and also, a decrease in cytokines. Conclusion: Therefore, the use of probiotics should be encouraged

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益生菌:预防和治疗炎性疾病的治疗策略:肥胖、2型糖尿病和乳糜泻

背景:最近的证据表明肠道微生物群在炎症性疾病中的基本作用，以及益生菌在改善炎症参数中的几种作用机制。目的:本综述的目的是研究益生菌的摄入及其对炎症性疾病的影响，包括肥胖、II型糖尿病和乳糜泻。方法:检索2011年至2022年间的英文研究文章以及人体和体内研究的临床试验。研究表明，使用益生菌可以改善心血管风险指标，改善胰岛素敏感性，血脂和血浆动脉粥样硬化指数。2型糖尿病患者空腹血糖、糖化血红蛋白、胰岛素和血糖指数下降，肽1、超氧化物歧化酶和谷胱甘肽过氧化物酶水平升高。结果:除对朗格汉斯胰岛有细胞保护作用外，TNF-α和IL-1β标志物均有阳性改变。乳糜泻患者的病情得到改善，因为观察到血清素水平失衡的中和，减少了相关基因的表达，也减少了细胞因子。结论:应提倡使用益生菌

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来源期刊

Current Nutrition & Food Science NUTRITION & DIETETICS-

CiteScore

2.00

自引率

0.00%

发文量

144

期刊介绍： Current Nutrition & Food Science publishes frontier reviews on all the latest advances on basic and clinical nutrition and food sciences. The journal aims to publish the highest quality review articles dedicated to research in the field. The journal is essential reading for all nutrition and food scientists.