Platelet and Erythrocyte Parameters in Type 2 Diabetic Moroccan Patients: A Cross-Sectional Study

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Ibtissam Mhirig, Sara Harrar, Leila Habibi, Sanae Sayagh, Siham Aboulmakarim
{"title":"Platelet and Erythrocyte Parameters in Type 2 Diabetic Moroccan Patients: A Cross-Sectional Study","authors":"Ibtissam Mhirig, Sara Harrar, Leila Habibi, Sanae Sayagh, Siham Aboulmakarim","doi":"10.1055/s-0043-1774811","DOIUrl":null,"url":null,"abstract":"Abstract Introduction Complete blood count parameters have gained renewed interest as predictors of endothelial dysfunction in type 2 diabetes mellitus (T2DM). Thus, the aim of this study was to observe the changes in platelet and erythrocyte parameters between diabetics and nondiabetics and to evaluate these changes in relation to glycemic control. Materials and Methods This cross-sectional study was performed in Mohammed VI University Hospital, Marrakech, Morocco, from January 2020 to July 2021. A total of 307 Moroccan patients were enrolled in this study, which included 222 diabetic patients and 85 nondiabetics. The diabetic patients were divided into two groups A (hemoglobin A1c [HbA1c] ≥ 6.5%) and B (HbA1c < 6.5%) according to their glycated hemoglobin levels (HbA1c). Biological parameters were processed as per the standard technique. Data analysis was performed using SPSS statistical software. Results A significant difference was mentioned regarding mean corpuscular volume (MCV) (p < 0.001), red blood cell distribution width (RDW) (p < 0.001), and volume/platelet count (p = 0.023) between diabetics and nondiabetics. MCV and RDW were lower in group B than group A (p = 0.004; p = 0.04), while MPV was higher (p = 0.342). RDW significantly and negatively correlated with HbA1c in diabetic population (r = –0.182; p = 0.006). On the other hand, a significant and positive correlation between MPV and HbA1c was mentioned (r = +0.184; p = 0.006). Conclusion Our study showed that RDW and MPV correlate with HbA1c in T2DM and can be used as a reproducible and inexpensive means to ensure proper control of glycemic status. Further studies are warranted to define specific RDW and MPV values predictive of complication risk in the diabetic population.","PeriodicalId":16149,"journal":{"name":"Journal of Laboratory Physicians","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Laboratory Physicians","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0043-1774811","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract Introduction Complete blood count parameters have gained renewed interest as predictors of endothelial dysfunction in type 2 diabetes mellitus (T2DM). Thus, the aim of this study was to observe the changes in platelet and erythrocyte parameters between diabetics and nondiabetics and to evaluate these changes in relation to glycemic control. Materials and Methods This cross-sectional study was performed in Mohammed VI University Hospital, Marrakech, Morocco, from January 2020 to July 2021. A total of 307 Moroccan patients were enrolled in this study, which included 222 diabetic patients and 85 nondiabetics. The diabetic patients were divided into two groups A (hemoglobin A1c [HbA1c] ≥ 6.5%) and B (HbA1c < 6.5%) according to their glycated hemoglobin levels (HbA1c). Biological parameters were processed as per the standard technique. Data analysis was performed using SPSS statistical software. Results A significant difference was mentioned regarding mean corpuscular volume (MCV) (p < 0.001), red blood cell distribution width (RDW) (p < 0.001), and volume/platelet count (p = 0.023) between diabetics and nondiabetics. MCV and RDW were lower in group B than group A (p = 0.004; p = 0.04), while MPV was higher (p = 0.342). RDW significantly and negatively correlated with HbA1c in diabetic population (r = –0.182; p = 0.006). On the other hand, a significant and positive correlation between MPV and HbA1c was mentioned (r = +0.184; p = 0.006). Conclusion Our study showed that RDW and MPV correlate with HbA1c in T2DM and can be used as a reproducible and inexpensive means to ensure proper control of glycemic status. Further studies are warranted to define specific RDW and MPV values predictive of complication risk in the diabetic population.
摩洛哥2型糖尿病患者的血小板和红细胞参数:一项横断面研究
作为2型糖尿病(T2DM)内皮功能障碍的预测指标,全血细胞计数参数重新引起了人们的兴趣。因此,本研究的目的是观察糖尿病患者和非糖尿病患者血小板和红细胞参数的变化,并评估这些变化与血糖控制的关系。材料和方法本横断面研究于2020年1月至2021年7月在摩洛哥马拉喀什穆罕默德六世大学医院进行。共有307名摩洛哥患者参加了这项研究,其中包括222名糖尿病患者和85名非糖尿病患者。将糖尿病患者分为A组(血红蛋白A1c [HbA1c]≥6.5%)和B组(HbA1c <6.5%)根据他们的糖化血红蛋白水平(HbA1c)。生物学参数按标准工艺处理。采用SPSS统计软件进行数据分析。结果两组患者的平均红细胞体积(MCV)差异有统计学意义(p <0.001),红细胞分布宽度(RDW) (p <0.001),糖尿病患者和非糖尿病患者的体积/血小板计数(p = 0.023)。B组MCV、RDW低于A组(p = 0.004;p = 0.04),而MPV较高(p = 0.342)。糖尿病人群中RDW与HbA1c呈显著负相关(r = -0.182;P = 0.006)。另一方面,MPV与HbA1c呈显著正相关(r = +0.184;P = 0.006)。结论我们的研究表明,RDW和MPV与T2DM患者的HbA1c相关,可以作为一种可重复且廉价的方法来确保血糖状态的适当控制。需要进一步的研究来确定预测糖尿病人群并发症风险的具体RDW和MPV值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Laboratory Physicians
Journal of Laboratory Physicians MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
99
审稿时长
31 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信