Synthesis and biological evaluation of [1,2,3]triazolo[4',5':3,4]pyrrolo[1,2-a] indoles: one-pot reaction under microwave irradiation

Abstract

: The synthesis and structural determination of several new fused [1,2,3]triazolo-[4',5':3,4]pyrrolo-[1,2-a ]indole derivatives ( 4a-4p ) utilising 1 HNMR, 13 CNMR, and mass spectrum analysis were discussed. The in vitro antibacterial activity of the compounds ( 4a-4p ) against three gramme positive bacterial strains such as B.subtilis , S.aureus , and S.epidermidis revealed that the compounds 4h , 4j , and 4k demonstrated greater activity than the remaining compounds. Compounds 4d , 4i , and 4l had comparable activity to the standard. The antioxidant activity screening findings show that compounds 4c , 4d , and 4j have higher activity than conventional Trolox. Compounds 4b , 4h , 4k , and 4l have high activity, whereas the remaining compounds have moderate to low activity.