Peripheral clinico-chemical parameters in experimentally naive versus morphine tolerant mice: evidence for development of clinico-chemical tolerance.

Abstract

Changes in peripheral clinico-chemical parameters (packed cell volume (PCV), hemoglobin (HGB), serum glucose, carbamide nitrogen (CN), sodium, uric acid and creatinine) were investigated in mice during the development of acute morphine tolerance. Acute morphine treatment (in drug-naive organism) altered the PCV, HGB, serum glucose and CN levels in a naloxone-reversible manner. Acute tolerance developed in PVC, HGB, sodium and CN values. The data raise the possibility of a relationship between clinico-chemical and pharmacological tolerance.