Urtica dioica (Nettle) in Type 1 Diabetes Mellitus: A Randomized Controlled Trial

IF 0.4 4区医学 Q4 PEDIATRICS

Iranian Journal of Pediatrics Pub Date : 2023-10-09 DOI:10.5812/ijp-137563

Maryam Shahrokhi, Shahin Koohmanaee, Reyhaneh Haghghi, Afagh Hassanzadeh Rad, Mohammad Ali Esfandiari, Shirin Parvinroo, Setila Dalili

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引用次数: 0

Abstract

Background: As the role of nettle supplementation for type 1 diabetic patients is still unclear, we aimed to evaluate the impact of nettle supplementation on children with type 1 diabetes mellitus. Methods: In this single-blind randomized controlled trial, 50 patients with type one diabetes aged 12 - 18 with improper glycemic parameters (HbA1c greater than 6.5 mg/dL) received either insulin with 5 cc of nettle syrup (i.e., quercetin-based on at least 0.04 mg/mL of chlorogenic acid) twice daily for 12 weeks, or insulin monotherapy. Demographic characteristics, fasting blood sugar, HbA1c, blood urea nitrogen (BUN), serum creatinine, and insulin dosage were investigated at the beginning of the study and at multiple intervals in both groups. Results: Changes in fasting blood sugar (FBS), HbA1c, mean dose of rapid-acting and long-acting insulin, and mean total insulin dose were significant in both groups, and the increase in total insulin dose was significantly lower in the intervention group (P < 0.05). The trend of BUN and serum creatinine changes was not significant over time (P = 0.532 and P = 0.785, respectively). Conclusions: We found lower total insulin dose in the intervention group that may emphasize the positive effect of nettle concomitant use through insulin secretion or sensitizing effect.

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1型糖尿病的荨麻:一项随机对照试验

背景:由于补充荨麻对1型糖尿病患者的作用尚不清楚，我们旨在评估补充荨麻对1型糖尿病儿童的影响。方法:在这项单盲随机对照试验中，50例12 - 18岁血糖参数不正确(HbA1c大于6.5 mg/dL)的1型糖尿病患者接受胰岛素加5毫升荨麻糖浆(即槲皮素基于至少0.04 mg/mL绿原酸)，每天两次，持续12周，或胰岛素单药治疗。在研究开始时和多间隔时间对两组患者的人口学特征、空腹血糖、糖化血红蛋白(HbA1c)、尿素氮(BUN)、血清肌酐和胰岛素剂量进行调查。结果:两组患者空腹血糖(FBS)、糖化血红蛋白(HbA1c)、速效和长效胰岛素平均剂量、胰岛素平均总剂量的变化均有显著性差异，干预组患者胰岛素总剂量的升高明显低于干预组(P <0.05)。BUN和血清肌酐随时间变化趋势无统计学意义(P = 0.532, P = 0.785)。结论:干预组胰岛素总剂量较低，可能通过胰岛素分泌或增敏作用强调了荨麻合用的积极作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Pediatrics 医学-小儿科

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.