RENAL FUNCTION DYNAMICS IN PATIENTS WITH RADICAL PROSTATECTOMY FOR PROSTATIC ADENOCARCINOMA

Abstract

FOR PROSTATIC ADENOCARCINOMA (Abstract): Renal function parameters, readily assessed through routine blood tests, have been largely unexplored in relation to prostate cancer. This study aims to investigate the associations between renal function parameters (creatinine, urea, estimated glomerular filtration rate-eGFR), both pre-and post-prostatectomy, and histopathological characteristics of prostate adenocarcinomas. Additionally, it evaluates potential correlations with prostate biochemical recurrence, offering insights into kidney function dynamics post-prostatectomy. Material and methods: We analyzed data from 72 patients with prostate adenocarcinoma who underwent radical prostatectomy. Histopathological reevaluation was conducted, including Gleason score, pT stage, prognostic grade groups, and biochemical recurrence assessment. Preoperative and postoperative renal parameters were recorded, and eGFR was calculated using the CKD-EPI formula. Statistical analysis was performed to assess associations. Results: Preoperative eGFR showed a significant association with Gleason score and prognostic grade groups (p<0.05). However, there were no significant correlations between renal parameters and biochemical recurrence or pT stage. Conclusions: This study emphasizes the potential utility of eGFR as a marker for identifying prostate adenocarcinomas with higher Gleason scores and prognostic grade groups. While the complexity of renal function dynamics in prostate cancer warrants further investigation, our findings contribute to understanding the intricate relationship between kidney function and prostate tumor behavior.