Safety of Herbal Medicines on Liver Function in Functional Dyspepsia Patients: A Single-Center Retrospective Study

The Journal of Internal Korean Medicine Pub Date : 2023-09-30 DOI:10.22246/jikm.2023.44.4.635

Aram Han, Chang-Yul Keum, Chae-Rim Yoon, Su-Hyun Choi, Dahee Jeong, Nahyun Jeong, Hae-in Jeong, Na-Yeon Ha, Jinsung Kim

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Abstract

Objectives: This study analyzed laboratory serum data results before and after patients took herbal medicine to confirm the clinical safety of herbal medicine. In addition, in the event of liver damage, the case was analyzed to confirm the characteristics of liver damage and the possibility of liver damage caused by herbal medicine.Methods: A retrospective chart review of the effects of herbal medicine on liver function in patients diagnosed with functional dyspepsia was conducted. The electronic medical records of 128 patients in a single hospital were reviewed.Results: The statistical analysis revealed a statistically significant decrease in liver function-related laboratory serum data after taking herbal medicine (p<0.05). In addition, among 128 patients, there were two cases of drug-induced liver injury (DILI) (1.56%).Conclusion: Taking herbal medicine prescribed by experts does not significantly affect liver function in patients with functional dyspepsia. Rather, the liver levels of the subjects showed a significant decrease after taking herbal medicine. To support these results, further large-scale multicenter prospective studies are necessary.

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中药对功能性消化不良患者肝功能的安全性:一项单中心回顾性研究

目的:分析患者服用中药前后的实验室血清数据结果，以证实中药的临床安全性。此外，在发生肝损害的情况下，对病例进行分析，以确认肝损害的特点和草药引起肝损害的可能性。方法:回顾性分析中药对功能性消化不良患者肝功能的影响。对一家医院128名患者的电子病历进行了审查。结果:经统计学分析，服用中药后肝功能相关实验室血清数据下降有统计学意义(p<0.05)。此外，128例患者中，药物性肝损伤(DILI) 2例(1.56%)。结论:功能性消化不良患者服用专家处方中草药对肝功能无明显影响。相反，服用草药后，受试者的肝脏水平明显下降。为了支持这些结果，进一步的大规模多中心前瞻性研究是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Journal of Internal Korean Medicine

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