Anti-wrinkle and anti-inflammation effects of Camellia sinensis seed extracts

Association for International Tea Culture Pub Date : 2023-09-30 DOI:10.21483/qwoaud.61..202309.57

Hee-kyung Lee, Hyun-Suk Choi, Dubok Choi

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Abstract

The aim of this study was to investigate toxicity, elastase inhibitory activity, collagenase inhibitory activity, procollagen biosynthesis, hyaluronidase inhibitory activity and nitric oxide production inhibitory activity for improving anti-wrinkle and anti-inflammation using different extracts obtained from Camellia sinensis seeds. All extracts showed no cytotoxicity to Hs68 cell within 500 μg/mL. Among various extracts, elastase and collagenase inhibitory activities showed the highest inhibitory activity of 58.6% and 69.1% in 500 μg/mL of ethanol extract, respectivey. Procollagen biosynthesis showed high activity at 158.8% and 157.6% at 500 μg/mL of ethylacetate extract and ethanol extract, respectively. Hyaluronidase inhibitory activity showed the highest inhibitory activity at 31.2% in 500 μg/mL of ethylacetate extract, and nitric oxide production inhibitory activity showed high inhibitory activity at 40.4% in 500μg/mL of ethylacetate extract. The hyaluronidase and nitric oxide production was suppressed in ethylacetate extract, and it is considered that it can be applied to the treatment of inflammatory diseases. Taken together, the ethanol and ethylacetate extracts of C. sinensis seeds used in this study can be expected for skin protection and anti-inflammatory effects.

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山茶籽提取物的抗皱抗炎作用

摘要本研究旨在探讨山茶种子不同提取物的毒性、弹性酶抑制活性、胶原酶抑制活性、前胶原生物合成、透明质酸酶抑制活性和一氧化氮生成抑制活性对抗皱和抗炎作用的影响。所有提取物在500 μg/mL范围内对Hs68细胞无细胞毒性。其中，500 μg/mL乙醇提取物对弹性酶和胶原酶的抑制活性最高，分别为58.6%和69.1%。在500 μg/mL乙酸乙酯和乙醇提取物浓度下，前胶原合成活性分别为158.8%和157.6%。500μg/mL乙酸乙酯提取物对透明质酸酶的抑制活性最高，为31.2%;500μg/mL乙酸乙酯提取物对一氧化氮生成的抑制活性最高，为40.4%。乙酸乙酯提取物抑制了透明质酸酶和一氧化氮的产生，认为可以应用于炎症性疾病的治疗。综上所述，本研究中使用的三叶草种子乙醇和乙酸乙酯提取物具有皮肤保护和抗炎作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Association for International Tea Culture

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