Assessment of Anti-biofilm Activity of Ferns Against Nosocomial Pathogenic Bacteria

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2750

Saloni Saloni, Sarika Suresh

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Abstract

The rapid increase in drug resistance in nosocomial pathogens has warranted the search for novel treatment strategies. Targeting quorum sensing (QS) found in bacteria is opined as an alluring method as many pathogenic bacteria employ QS to modulate their virulence. Plants with an enchanting repertoire of phytochemicals can serve as the source for anti-QS compounds. Ferns, the vascular plants have been reported to be used for treating various ailments in traditional systems of medicine. Although some studies have described the antibacterial activity of ferns, to the best of our knowledge there are no investigations carried out to explore their anti-QS potential. Against this background, the current investigation aimed at identifying the anti-QS activity of ferns in inhibiting biofilm formation in selected nosocomial pathogens. Of the several ferns tested, hexane extract of Psilotumnudum leaf and ethanol extract of Cheilanthestenuifolia leaf exhibited significant anti-biofilm activity against S. aureus and E. coli respectively. There was a marked reduction in biofilm formation of approximately 80%. The presence of anti-QS compounds in these ferns paves way for further research to isolate and identify them.

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蕨类植物抗医院病原菌生物膜活性评价

医院内病原菌耐药性的迅速增加使得寻找新的治疗策略成为必要。靶向群体感应(targeted quorum sensing, QS)被认为是一种有吸引力的方法，因为许多致病菌都利用QS来调节它们的毒力。具有丰富的植物化学物质的植物可以作为抗qs化合物的来源。据报道，蕨类植物是一种维管植物，在传统医学体系中被用于治疗各种疾病。虽然一些研究已经描述了蕨类植物的抗菌活性，但据我们所知，还没有开展调查来探索其抗qs的潜力。在此背景下，本研究旨在鉴定蕨类植物在抑制选定医院病原菌生物膜形成中的抗qs活性。在几种蕨类植物中，裸蕨叶的己烷提取物和大头菜叶的乙醇提取物分别对金黄色葡萄球菌和大肠杆菌具有显著的抗生物膜活性。生物膜的形成明显减少了约80%。这些蕨类植物中抗qs化合物的存在为进一步分离和鉴定它们铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.