A Review on Animal Models of Chronic Kidney Disease- An Update

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2711

Deepthi R, Suhasin Ganta

引用次数: 0

Abstract

Chronic kidney disease is a global health burden and is an independent risk factor for morbidity and mortality for many diseases. The estimated prevalence of CKD worldwide is 9.1% (697.5 million cases) in all the age groups and about 1·2 million people died from CKD in 2017. Proteinuria and decreased glomerular filtration rate are the major indicators of the kidney damage.The need for reliable models for increasing prevalence is apparent. Animal models allow analysis of complex disease pathophysiology, for introducing new drugs and interventions in CKD. Studying various models will help in selection of appropriate model suitable for the cause of CKD.

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慢性肾脏疾病动物模型研究进展

慢性肾脏疾病是一个全球性的健康负担，是许多疾病发病率和死亡率的独立危险因素。据估计，全球所有年龄组CKD的患病率为9.1%(6.975亿例)，2017年约有120万人死于CKD。蛋白尿和肾小球滤过率降低是肾脏损害的主要指标。显然需要可靠的模型来说明发病率的增加。动物模型可以分析复杂的疾病病理生理，为CKD引入新的药物和干预措施。研究各种模型有助于选择适合CKD病因的模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

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