Antioxidant, Antibacterial and Cytotoxic Activities of Artemisia judaica, Ruta graveolens and Suaeda monoica from Saudi Arabia

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2723

Saida S. Ncibi, Aymen, M. Madkhali, Magbool E. Oraiby, Jamilah A. Almalki, Hussein A. Khadashi, Abdullah A. Mobarki, Syam Mohan, Hassan A. Hamali

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引用次数: 0

Abstract

Artemisia judaica, Ruta graveolens, and Suaeda monoica, indigenous plants to Jazan, second smallest region of Saudi Arabia, have several uses in the local folk medicine. This research aims to study the chemical composition of their methanol extracts and to explore some related biological activities. The different extracts Gas Chromatography Mass Spectroscopy profiling revealed the occurrence of many compounds within these extracts. Besides, this study revealed varied and selective antibacterial activities of these extracts. Ruta graveolens methanol extract was effective in inhibiting the growth of all tested microorganisms. Furthermore, they exhibit an interesting cytotoxic effect on human breast cancer cell lines, especially Artemisia judaica methanol extract. These findings suggested that Artemisia judaica (Asteraceae), Ruta graveolens (Rutaceae), and Suaeda monoica (Chenopodiaceae) could be natural sources for the discovery of new drugs.

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沙乌地阿拉伯产犹太蒿、荆芥和沙乌地阿拉伯的抗氧化、抗菌和细胞毒活性

沙特阿拉伯第二大地区吉赞(Jazan)的本土植物——犹太蒿(Artemisia judaica)、沙乌地蒿(Ruta graveolens)和沙乌地蒿(Suaeda monoica)，在当地民间医药中有几种用途。本研究旨在研究其甲醇提取物的化学成分，并探讨其相关的生物活性。不同提取物的气相色谱质谱分析揭示了这些提取物中许多化合物的存在。此外，本研究还揭示了这些提取物的多种选择性抗菌活性。芦花甲醇提取物对所有被试微生物的生长均有抑制作用。此外，它们还对人乳腺癌细胞系表现出有趣的细胞毒作用，特别是对青蒿甲醇提取物。这些研究结果提示，菊科蒿、芸香蒿和藜藓属植物可能是开发新药的天然资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.