3C. 3-Ketosteroid receptors in GtoPdb v.2023.1

Derek Cain, John Cidlowski, Dean P. Edwards, Peter Fuller, Sandra L. Grimm, Sean Hartig, Carol A. Lange, Robert H. Oakley, Jennifer K. Richer, Carol A. Sartorius, Marc Tetel, Nancy Weigel, Morag J. Young
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Abstract

Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 218, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone and 17β-estradiol) and 3-ketosteroids (dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone). For rodent GR and MR, the physiological ligand is corticosterone rather than cortisol.
3 c。GtoPdb v.2023.1中的3-酮类固醇受体
类固醇激素受体(由NC-IUPHAR核激素受体小组委员会商定的命名法[75,218,3])是NR3类核激素受体,其内源性激动剂可分为3-羟基类固醇(雌酮和17β-雌二醇)和3-酮类固醇(二氢睾酮[DHT]、醛固酮、皮质醇、皮质酮、孕酮和睾酮)。对于啮齿动物GR和MR,生理配体是皮质酮而不是皮质醇。
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