REVISÃO DO FOTOSSENSIBILIZADOR FTALOCIANINA UTILIZADA NA TERAPIA FOTODINÂMICA E SUA APLICABILIDADE FRENTE AO TRATAMENTO DE DIVERSOS AGENTES PATOGÊNICOS

Abstract

Photodynamic therapy (PDT) is a treatment modality already used in several countries to treat invasive and topical diseases. In these treatments, the combination of a photoactive drug (PS), visible light, and molecular oxygen results in the formation of singlet oxygen, a type of highly reactive/cytotoxic oxygen species. Phthalocyanines incorporated into solubilization/monomerization systems are photosensitizing substances used in PDT, even given their high hydrophobicity. Its inhibitory capacity against microorganisms and its photodynamic action against various cancer cell lines have made it the protagonist of several scientific articles. This review article provides a brief overview of the concept of PDT and its potential use in the treatment of diseases - an emerging treatment modality in Brazil.