Moderate Intensity Exercise Reduces Side Effects of Cancer Therapy and Maintains Cardiorespiratory Fitness in Male Breast Cancer Patients: Findings from the BRECA Male Crossover Study

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Breast Care Pub Date : 2023-09-14 DOI:10.1159/000534090

Eva B. Schultz, Damir Zubac, Wilhelm Bloch, Hansjörg Baurecht, Jana Rickert, Freerk T. Baumann

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引用次数: 0

Abstract

Introduction: There is growing evidence that aerobic exercise mitigates cancer therapy-related side effects and improves cardiorespiratory fitness (CRF). However, to the best of our knowledge, no exercise study has been conducted in male breast cancer (MBC) patients. The aim of this study was to investigate the feasibility and efficacy of different exercise intensities on CRF and self-reported questionnaire items in MBC patients. Methods: Twenty-two MBC patients (60 ± 9 years) participated in this randomized crossover study. After completion of medical treatment, MBC patients were randomly assigned to either moderate (40–50% of heart rate [HR] max. and self-perceived exertion: 11) or vigorous (70–80% of HR max. and self-perceived exertion: 15) exercise intensity during the first 3 months of the study. After a 1-month washout period, participants switched group assignments. Primary endpoints were CRF and questionnaire items. Results: We observed a dropout rate of 36% over 7 months, with the number of participants decreasing from 22 to 14. The results showed significant improvements in “Physical Function” (p = 0.037) and “Social Function” (p = 0.016) after moderate training. A non-significant improvement was also observed in “Breast Symptoms” (p = 0.095), but there was no change in “Fatigue” (p = 0.306). There were no differences observed in cardiovascular fitness (V̇O₂ peak) between the treatment groups. Conclusion: This study emphasizes the effectiveness of exercise intervention for an exceedingly rare cancer, highlighting the vital role of moderate intensity aerobic exercise in mitigating treatment side effects. Despite minimal peak V̇O₂ differences, both exercise protocols adequately sustain CRF. Future studies are imperative to design optimized, sex-specific rehabilitation strategies tailored to the unique requirements of MBC patients, advancing our understanding of this under explored realm.

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中等强度运动减少癌症治疗的副作用并维持男性乳腺癌患者的心肺健康:来自BRECA男性交叉研究的发现

& lt; b> & lt; i>简介:& lt; / i> & lt; / b>越来越多的证据表明，有氧运动可以减轻癌症治疗相关的副作用，并改善心肺健康(CRF)。然而，据我们所知，尚未对男性乳腺癌(MBC)患者进行过运动研究。本研究旨在探讨不同运动强度对MBC患者CRF及自述问卷项目的影响。& lt; b> & lt; i>方法:& lt; / i> & lt; / b>22例MBC患者(60±9岁)参加了这项随机交叉研究。治疗结束后，MBC患者被随机分配到中度(心率[HR] max的40-50%)。和自我感觉劳累:11)或剧烈(70-80%的HR max。自我感觉的运动强度:研究前三个月的运动强度。在一个月的洗脱期后，参与者交换了小组分配。主要终点为CRF和问卷项目。& lt; b> & lt; i>结果:& lt; / i> & lt; / b>我们观察到7个月的辍学率为36%，参与者人数从22人减少到14人。结果显示，“身体功能”(p= 0.037)和“社会功能”(p= 0.016)。在“乳房症状”(p)中也观察到无显著改善。= 0.095)，但“疲劳”没有变化(p= 0.306)。两组间的心血管适应度(V O2峰值)。& lt; b> & lt; i>结论:& lt; / i> & lt; / b>这项研究强调了运动干预对一种极其罕见的癌症的有效性，强调了中等强度有氧运动在减轻治疗副作用方面的重要作用。尽管有最小的峰值V值O2不同的是，两种运动方案都能充分维持CRF。未来的研究必须针对MBC患者的独特需求，设计优化的、针对性别的康复策略，以促进我们对这一尚未探索的领域的理解。

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来源期刊

Breast Care 医学-妇产科学

CiteScore

4.40

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Breast Care'' is a peer-reviewed scientific journal that covers all aspects of breast biology. Due to its interdisciplinary perspective, it encompasses articles on basic research, prevention, diagnosis, and treatment of malignant diseases of the breast. In addition to presenting current developments in clinical research, the scope of clinical practice is broadened by including articles on relevant legal, financial and economic issues.