Cytotoxic potential of nanoliposomes on hCMEC/D3 and SH-SY5Y cell lines

Abstract

It is well known that nanoliposomes (NLs) are considered as pharmacologically inactive vesicles, exhibiting minimal toxicity. Despite their biocompatibility and cell membrane structure similarity, it is important to highlight that their potential cytotoxicity is tightly related to the cell culture model, exposure time and dose as well as NLs physicochemical and surface properties including lipid composition, size, surface charge, PEGylation and others (Inglut et al., 2020; Syama et al., 2022). Therefore, the aim of this study was to investigate the cytotoxic potential of different formulations of NLs on two different cell culture lines