Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2023-09-26 DOI:10.5812/ans-139049

Aida Afghani, Emran M Razaghi, Reza Rastgoo Sisakht, Ali Farhoudian, Nasim Vousooghi

引用次数: 0

Abstract

Background: Preclinical studies have shown that neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), are involved in the modulation of biochemical and behavioral adaptations to substance use. Methods: We studied the impact of GDNF and BDNF serum levels on adherence to methadone maintenance treatment (MMT) through cross-sectional research. Participants were clients on MMT (43 males), subjects in remission from opioid use disorder (12 males), and healthy controls (20 males). Adherence and non-adherence to treatment were assessed by the detection of illicit opioids in random urinalysis. Results: Using t-tests for independent groups and analysis of variance (ANOVA), GDNF serum levels in the adherent patients to MMT were found to be significantly higher than in the non-adherent patients. BDNF serum levels were not different between adherent and non-adherent patients. Conclusions: Our results suggest the involvement of GDNF as a biological factor in adherence to MMT.

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血清GDNF水平与美沙酮维持治疗依从性相关

背景:临床前研究表明，神经营养因子，包括脑源性神经营养因子(BDNF)和神经胶质细胞系源性神经营养因子(GDNF)，参与调节对物质使用的生化和行为适应。方法:通过横断面研究研究血清GDNF和BDNF水平对美沙酮维持治疗(MMT)依从性的影响。参与者包括MMT患者(43名男性)、阿片类药物使用障碍缓解者(12名男性)和健康对照组(20名男性)。通过随机尿液分析中非法阿片类药物的检测来评估依从性和不依从性。结果:采用独立组t检验和方差分析(ANOVA)，发现MMT依从患者血清GDNF水平显著高于非MMT依从患者。血清BDNF水平在粘附和非粘附患者之间没有差异。结论:我们的结果表明GDNF作为一个生物学因素参与了MMT的坚持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archives of Neuroscience NEUROSCIENCES-

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期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.