Enhanced identification and localization of metabolites in Scutellariae Radix using ion mobility enabled MALDI-Q-TOF/MS imaging

IF 6.1 1区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Analysis Pub Date : 2023-10-01 DOI:10.1016/j.jpha.2023.09.018

Lixing Nie, Lieyan Huang, Xiaofei Jia, Shuai Kang, Lingwen Yao, Yanpei Wu, Hao Yuan, Yongli Liu, Feng Wei, Hongyu Jin, Xiang Li, Shuangcheng Ma

引用次数: 0

Abstract

• MALDI-IM-MS localization of metabolites in Scutellariae Radix was conducted for the first time. • Mobility- m / z plot offered distinct separation of endogenous metabolites from matrix. • Exclusive trend line enabled more selective characterization of flavonoids.

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利用离子迁移的MALDI-Q-TOF/MS成像技术增强了黄芩代谢物的识别和定位

•首次对黄芩中代谢物进行了MALDI-IM-MS定位。•迁移率- m / z图显示了内源代谢物与基质的明显分离。•独有的趋势线使黄酮类化合物的表征更具选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmaceutical Analysis Chemistry-Electrochemistry

CiteScore

16.20

自引率

2.30%

发文量

674

审稿时长

22 weeks

期刊介绍： The Journal of Pharmaceutical Analysis (JPA), established in 2011, serves as the official publication of Xi'an Jiaotong University. JPA is a monthly, peer-reviewed, open-access journal dedicated to disseminating noteworthy original research articles, review papers, short communications, news, research highlights, and editorials in the realm of Pharmacy Analysis. Encompassing a wide spectrum of topics, including Pharmaceutical Analysis, Analytical Techniques and Methods, Pharmacology, Metabolism, Drug Delivery, Cellular Imaging & Analysis, Natural Products, and Biosensing, JPA provides a comprehensive platform for scholarly discourse and innovation in the field.