Predictive model for determination of relative ABCB1 gene expression in different tissues

Abstract

The ABCB1 gene has 14 single nucleotide polymorphisms that are associated with the pharmacokinetic response to drugs (Wang and Sadée, 2006). Three of them (C1236T, C3435T and G2677T/A are subject of most intensive research and their influence on the expression and activity of P-glycoprotein in humans and the pharmacokinetics of drugs that are substrates of this transporter has been confirmed with the large number of studies evaluating the influence of haplotype inheritance (Fukui et al., 2007; Wang et al., 2005). The aim of this paper is to create a predictive model that will be able to determine the relative expression of the ABCB1 gene in the blood and the correlation with the expression in the brain, liver, kidney, duodenum, jejunum, ileum and colon.