The Influence of Pre-Existing Immunity against Human Common Cold Coronaviruses on COVID-19 Susceptibility and Severity

IF 2.1 Q3 MICROBIOLOGY

Microbiology Research Pub Date : 2023-09-14 DOI:10.3390/microbiolres14030093

Erick De La Torre Tarazona, Daniel Jiménez, Daniel Marcos-Mencía, Alejandro Mendieta-Baro, Alejandro Rivera-Delgado, Beatriz Romero-Hernández, Alfonso Muriel, Mario Rodríguez-Domínguez, Sergio Serrano-Villar, Santiago Moreno

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引用次数: 0

Abstract

The susceptibility to SARS-CoV-2 infection and the severity of COVID-19 manifestations vary significantly among individuals, prompting the need for a deeper understanding of the disease. Our objective in this study was to investigate whether previous infections with human common cold coronaviruses (hCCCoV) might impact susceptibility to and the progression of SARS-CoV-2 infections. We assessed the serum antibody levels against SARS-CoV-2 and four hCCCoV (H-CoV-OC43, -NL63, -HKU1, and -229E) in three distinct populations: 95 uninfected individuals (COVID-19-negative), 83 individuals with mild or asymptomatic COVID-19 (COVID-19-mild), and 45 patients who died due to COVID-19 (COVID-19-severe). The first two groups were matched in terms of their exposure to SARS-CoV-2. We did not observe any differences in the mean antibody levels between the COVID-19-mild and the COVID-19-negative participants. However, individuals in the COVID-19-mild group exhibited a higher frequency of antibody levels (sample/control) > 0.5 against H-CoV-HKU1, and >1 against H-CoV-229E and -OC43 (p < 0.05). In terms of severity, we noted significantly elevated H-CoV-NL63 IgG levels in the COVID-19-severe group compared to the other groups (p < 0.01). Our findings suggest a potential mild influence of hCCCoV antibody levels on the susceptibility to SARS-CoV-2 infection and the severity of COVID-19. These observations could aid in the development of strategies for predicting and mitigating the severity of COVID-19.

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已有的人类普通感冒冠状病毒免疫对COVID-19易感性和严重程度的影响

个体对SARS-CoV-2感染的易感性和COVID-19表现的严重程度存在显著差异，需要对该疾病进行更深入的了解。本研究的目的是调查先前感染人类普通感冒冠状病毒(hCCCoV)是否会影响对SARS-CoV-2感染的易感性和进展。我们在三个不同的人群中评估了针对SARS-CoV-2和四种hCCCoV (H-CoV-OC43、-NL63、-HKU1和-229E)的血清抗体水平:95名未感染者(COVID-19阴性)、83名轻度或无症状COVID-19患者(COVID-19轻度)和45名因COVID-19死亡的患者(COVID-19重度)。前两组在接触SARS-CoV-2方面是匹配的。我们没有观察到covid -19轻度和covid -19阴性参与者之间的平均抗体水平有任何差异。然而，covid -19轻度组的个体表现出更高的抗体水平频率(样本/对照)>H-CoV-HKU1为0.5,H-CoV-229E和-OC43为1 (p <0.05)。在严重程度方面，我们注意到covid -19严重组的H-CoV-NL63 IgG水平明显高于其他组(p <0.01)。我们的研究结果表明，hCCCoV抗体水平对SARS-CoV-2感染的易感性和COVID-19的严重程度可能有轻微的影响。这些观察结果有助于制定预测和减轻COVID-19严重程度的战略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology Research MICROBIOLOGY-

CiteScore

1.90

自引率

6.70%

发文量

审稿时长

10 weeks

期刊介绍： Microbiology Research is an international, online-only, open access peer-reviewed journal which publishes original research, review articles, editorials, perspectives, case reports and brief reports to benefit researchers, microbiologists, physicians, veterinarians. Microbiology Research publishes ‘Clinic’ and ‘Research’ papers divided into two different skill and proficiency levels: ‘Junior’ and ‘Professional’. The aim of this four quadrant grid is to encourage younger researchers, physicians and veterinarians to submit their results even if their studies encompass just a limited set of observations or rely on basic statistical approach, yet upholding the customary sound approach of every scientific article.