Application of chloride in cold atmospheric plasma jet (CAPJ) and plasma-activated solution (PAS) to enhance virus inactivation

Q3 Physics and Astronomy

Plasma Medicine Pub Date : 2023-01-01 DOI:10.1615/plasmamed.2023051186

Qing Huang, Han Wang, Chao Liu, Yahui Wu, Mona Alrasheed Bashir, Changsheng Shao

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引用次数: 0

Abstract

Viruses are serious pathogenic contaminants that gravely threaten human health. There is an urgent need for environment-friendly and novel disinfection methods to inactivate various viruses. In this study, we applied the technique of cold atmospheric plasma (CAP) for virus disinfection. Particularly, we utilized the cold atmospheric plasma jet (CAPJ) and the plasma-activated solution (PAS) approaches for the treatment of bacteriophage MS2, and we added NaCl in the treatment system to enhance the disinfection efficiency. The inactivation effects under different CAPJ-PAS conditions using various plasma working gases were investigated. Also, the involved inactivation mechanisms due to respective active species were scrutinized. Our results showed that the addition of NaCl could considerably enhance the virus inactivation efficiency in the air/oxygen-CAPJ-PAS treatment, and during the direct CAPJ treatment, the primary inactivation factors were attributed to ·OH, 1O2, ONOOH and active chlorine, while for the indirect PAS treatment, the major inactivation contributors stemmed from 1O2 and active chlorine. This work therefore demonstrates the usefulness of NaCl in the CAPJ-PAS treatment in the virus inactivation and offers new perspectives on the application of CAP technology in disinfection of viruses.

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氯化物在低温大气等离子体射流(CAPJ)和等离子体活化溶液(PAS)中的应用以增强病毒灭活

病毒是严重威胁人类健康的严重致病性污染物。目前迫切需要一种环保的新型消毒方法来灭活各种病毒。本研究应用冷常压等离子体(CAP)技术对病毒进行消毒。其中，我们采用冷常压等离子体射流(CAPJ)和等离子体活化溶液(PAS)两种方法处理噬菌体MS2，并在处理系统中加入NaCl以提高消毒效率。研究了不同等离子体工作气体在不同CAPJ-PAS条件下的失活效果。此外，还详细分析了各自活性物种的失活机制。结果表明，在空气/氧气-CAPJ-PAS处理中，NaCl的加入可显著提高病毒的失活效率，且在直接CAPJ处理中，主要失活因子为·OH、1O2、ONOOH和活性氯，而在间接PAS处理中，主要失活因子为1O2和活性氯。因此，本研究证明了NaCl在CAPJ-PAS处理病毒灭活中的有效性，并为CAP技术在病毒消毒中的应用提供了新的视角。

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来源期刊

Plasma Medicine Physics and Astronomy-Physics and Astronomy (all)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Technology has always played an important role in medicine and there are many journals today devoted to medical applications of ionizing radiation, lasers, ultrasound, magnetic resonance and others. Plasma technology is a relative newcomer to the field of medicine. Experimental work conducted at several major universities, research centers and companies around the world over the recent decade demonstrates that plasma can be used in variety of medical applications. It is already widely used surgeries and endoscopic procedures. It has been shown to control properties of cellular and tissue matrices, including biocompatibility of various substrates. Non-thermal plasma has been demonstrated to deactivate dangerous pathogens and to stop bleeding without damaging healthy tissue. It can be used to promote wound healing and to treat cancer. Understanding of various mechanisms by which plasma can interact with living systems, including effects of reactive oxygen species, reactive nitrogen species and charges, has begun to emerge recently. The aim of the Plasma Medicine journal will be to provide a forum where the above topics as well as topics closely related to them can be presented and discussed. Existing journals on plasma science and technology are aimed for audiences with primarily engineering and science background. The field of Plasma Medicine, on the other hand, is highly interdisciplinary. Some of prospective readers and contributors of the Plasma Medicine journal are expected to have background in medicine and biology. Others might be more familiar with plasma science. The goal of the proposed Plasma Medicine journal is to bridge the gap between audiences with such different backgrounds, without sacrificing the quality of the papers be their emphasis on medicine, biology or plasma science and technology.