[Use of extracorporeal circulation in the treatment of 2,4-dichlorophenoxyacetic acid poisoning].

Abstract

The paper presents the course of illness in four patients poisoned by the 2,4-dichlorophenoxyacetic acid. The first patient, 50 years old, attempted suicide by taking 400 ml of 40% solution of the 2,4-dichlorophenoxyacetic acid (2,4-D). He was hospitalized in a comatous state 6 hours after intoxication. He was treated by the extracorporal hemodialysis and the course of the illness was successfull. The second patient, 80 years old, drank up 100 ml of 40% solution of 2,4-D accidentally. He was admitted in a comatous state a few hours after intoxication. He was treated by hemodialysis and resin hemoperfusion (XAD-4) successfully. Before treatment, the serum 2,4-D concentration reached 177 mg/100 ml, with the 2,4-D clearance of 56.3 ml/min. The third patient, 24 years old, attempted suicide by taking 200 ml 40% solution of 2,4-D, but it remained questionable whether it was 2,4-D or paraquat intoxication. He was admitted to hospital 10 hours after intoxication. He was treated by hemodialysis and hemoperfusion methods (XAD-4) successfully. The serum 2,4-D concentration reached the amount of 122.5 mg/100 ml, and the clearance of 2,4-D was 85.4 ml/min. The fourth patient, 50 years old, drank 100-200 ml of 40% solution of 2,4-D accidentally. He was hospitalized in a comatous state 3 hours after intoxication. He was treated by the hemodialysis method successfully. The serum 2,4-D concentration before the treatment reached the amount of 37 mg/100 ml, and the clearance of 2,4-D was 96 ml/min.(ABSTRACT TRUNCATED AT 250 WORDS)