STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer.

IF 4.1 Q2 CELL BIOLOGY
Cell Stress Pub Date : 2023-11-14 eCollection Date: 2023-11-01 DOI:10.15698/cst2023.11.291
Fabian Richter, Christophe Paget, Lionel Apetoh
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引用次数: 0

Abstract

Adoptive cell therapy (ACT) can successfully treat hematopoietic cancers but lacks efficacy against solid tumors. This is due to insufficient T cell infiltration, high tumor heterogeneity, frequent antigen loss with subsequent tumor escape, and the immunosuppressive tumor microenvironment (TME). Alternative methods to boost the anticancer efficacy of adoptively transferred cells are actively pursued. Among adjuvants that are utilized to stimulate anticancer immune responses, ligands of the stimulator of interferon genes (STING) pathway have received increasing attention. STING activation can trigger dendritic cell (DC) activation and endogenous immune responses, thereby preventing tumor escape. Activation of the STING pathway in the context of ACT was accordingly associated with improved T cell trafficking and persistence in the TME combined with the reduced presence of immunosuppressive cells. Recent findings also suggest cell-intrinsic effects of STING ligands on T cells. Activation of the STING signaling pathway was in this regard shown to enhance effector functions of CD4+ and CD8+ T cells, suggesting that the STING signaling could be exploited to harness T cell anticancer functions. In this review, we will discuss how the STING signaling can be used to enhance the anticancer efficacy of ACT.

sting驱动的T细胞活化:与癌症过继细胞治疗的相关性
过继细胞疗法(ACT)可以成功治疗造血肿瘤,但对实体肿瘤缺乏疗效。这是由于T细胞浸润不足,肿瘤异质性高,抗原丢失频繁,随后肿瘤逃逸,以及免疫抑制肿瘤微环境(TME)。提高过继性转移细胞的抗癌功效的替代方法正在积极寻求。在用于刺激抗癌免疫反应的佐剂中,干扰素基因刺激剂(STING)途径的配体越来越受到关注。STING激活可触发树突状细胞(DC)激活和内源性免疫反应,从而阻止肿瘤逃逸。因此,在ACT的背景下,STING通路的激活与T细胞运输的改善和TME中的持久性以及免疫抑制细胞的减少有关。最近的研究结果还表明,STING配体对T细胞具有细胞内在作用。在这方面,STING信号通路的激活被证明可以增强CD4+和CD8+ T细胞的效应功能,这表明STING信号通路可以利用T细胞的抗癌功能。在这篇综述中,我们将讨论如何利用STING信号来增强ACT的抗癌功效。
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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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