Successfully navigating the valley of death: the importance of accelerators to support academic drug discovery and development.

IF 6 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Maaike Everts, Mark Drew
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引用次数: 0

Abstract

Introduction: The drug discovery and development 'valley of death' remains a challenge for promising new therapies originating from academic research laboratories. Drug discovery support centers and accelerators have been established to provide monetary and scientific support, but limited available funding along with cultural and expertise gaps remain obstacles for many promising technologies.

Areas covered: In this meta-opinion article, the authors summarize the literature around obstacles that academic drug discovery projects face, along with potential solutions and best practices. Topics covered include funding challenges, regulatory education, reproducibility, along with cultural and organizational considerations. It describes one accelerator in particular-Critical Path Institute's Translational Therapeutics Accelerator (TRxA)-that aims to overcome several of the mentioned challenges.

Expert opinion: The 'valley of death' remains a stubborn but not insurmountable part of the academic drug discovery and development landscape. Purposely designed accelerators can help, complementing more traditional intra- and extramural funding support.

成功地导航死亡之谷:加速器对支持学术药物发现和开发的重要性。
药物发现和开发“死亡之谷”仍然是来自学术研究实验室的有前途的新疗法的挑战。已经建立了药物发现支持中心和加速器,以提供资金和科学支持,但有限的可用资金以及文化和专业知识差距仍然是许多有前途的技术的障碍。涵盖领域:在这篇元观点文章中,作者总结了围绕学术药物发现项目面临的障碍的文献,以及潜在的解决方案和最佳实践。涵盖的主题包括资金挑战、监管教育、可重复性以及文化和组织方面的考虑。它特别描述了一个加速器-关键路径研究所的转化治疗加速器(TRxA)-旨在克服上述几个挑战。专家意见:“死亡之谷”仍然是学术药物发现和开发领域中一个顽固但并非不可逾越的部分。有意设计的加速器可以提供帮助,补充更传统的校内和校外资金支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.20
自引率
1.60%
发文量
78
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Drug Discovery (ISSN 1746-0441 [print], 1746-045X [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on novel technologies involved in the drug discovery process, leading to new leads and reduced attrition rates. Each article is structured to incorporate the author’s own expert opinion on the scope for future development. The Editors welcome: Reviews covering chemoinformatics; bioinformatics; assay development; novel screening technologies; in vitro/in vivo models; structure-based drug design; systems biology Drug Case Histories examining the steps involved in the preclinical and clinical development of a particular drug The audience consists of scientists and managers in the healthcare and pharmaceutical industry, academic pharmaceutical scientists and other closely related professionals looking to enhance the success of their drug candidates through optimisation at the preclinical level.
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