Whole-Genome Sequencing to Determine Origin of Diarrhea in Suckling Piglets in Southern China

Jie Li, Jiating Qian, Xuanxuan Mao, C. Xue, Yongchang Cao
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Abstract

Severe diarrhea in suckling piglets occurred in southern China in 2017 and a new porcine coronavirus, named as porcine enteric alphacoronavirus (PEAV), was identified. Here we reported a detailed process to sequence, assemble and analyze the whole genome of PEAV. GDS04 has 87% amino acid identity comparing to the S proteins of the HKU2 strains without recombination, and their receptor-binding domains in S protein differ at 20 amino acids, suggesting that GDS04 could be a new mutant virus from bat-like CoVs and responsible for the most recent diarrhea endemic in pig herds in southern China.
全基因组测序确定中国南方哺乳仔猪腹泻的起源
2017年,中国南方发生了哺乳仔猪严重腹泻,并发现了一种名为猪肠道甲型冠状病毒(PEAV)的新型猪冠状病毒。本文报道了PEAV全基因组测序、组装和分析的详细过程。GDS04与未经重组的HKU2株的S蛋白具有87%的氨基酸同源性,其S蛋白的受体结合结构域存在20个氨基酸差异,提示GDS04可能是来自蝙蝠样冠状病毒的一种新的突变病毒,可能是导致中国南方猪群最近腹泻流行的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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