Comparison of Rotavirus A and Rotavirus D Segment 1 Using Apriori Algorithm, Decision Tree, and Support Vector Machine (SVM)

Abstract

Rotaviruses are the viruses that commonly cause gastroenteritis especially among infants and young children worldwide. Symptoms of rotavirus infection include diarrhea, fever, vomiting and dehydration. There are eight species of this virus: A, B, C, D, E, F, G and H. Among them, Rotavirus A is the most common species that cause more than 90% of rotavirus infections in humans whereas Rotavirus D is exclusively found in birds. We harbored suspicion on the factor that causes the difference in infection organisms of two viruses and attempted to compare and contrast segment 1 of Rotavirus A and D for deeper understanding of the specific difference in infection. In this study, we sought for any difference in genome and amino acid sequences between two viruses by applying three kinds of algorithms: Apriori algorithm, Decision Tree, and Support Vector Machine(SVM). Based on the results derived from these algorithms, we concluded that the functional difference in infection originates from the significant distribution of amino acids. Discovery of this relationship between frequencies of amino acids and differences in two viruses and especially characteristics of avian viral infections will contribute to the enhancement of the understanding rotavirus itself, and moreover, development of relevant vaccination for relevant forms of mutation.