Medial Temporal Lobe and Cortical Involvement: Neuroanatomical Signatures of Symptom Dimension Dominant Schizophrenia

Abstract

Methods: T1-weighted MRIs and symptom ratings (SAPS – Scale for Assessment of Positive Symptoms & SANS – Scale for Assessment of Negative Symptoms) were obtained from the open database SchizConnect (http://schizconnect. org/). Based on standard symptom remission criteria, subjects were grouped into Positive symptoms (n=29) and Negative symptoms predominant (n=84) groups and healthy controls (n=120). Structural-MRI analysis was performed on Freesurfer and the scanner site-harmonized brain volumes were compared across the 3 groups.